Effects of valsartan on ventricular arrhythmia induced by programmed electrical stimulation in rats with myocardial infarction.
Bottom Line: Valsartan effectively improved the cardiac function, reduced the prolonged QTc (163.7 ± 3.7 msec. versus 177.8 ± 4.5 msec., P < 0.05) after MI and the incidence of VT or VF evoked by PES (21.1% versus 55%, P < 0.05).The mRNA and protein expressions of Cx43 in BZ were significantly reduced after MI and up-regulated by valsartan.Increased collagen deposition and reduced Cx43 expression in BZ after MI could be partly attenuated by Valsartan.
Affiliation: Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.Show MeSH
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Mentions: The mRNA level of Cx43 in BZ and NIZ of MI group was significantly lower than in Sham group (P < 0.05) and the reduction was more significant in BZ than in NIZ; the mRNA level of Cx43 in BZ and NIZ was significantly higher in MI + Val group than in MI group. The protein expression of Cx43 in BZ was significantly reduced in MI group than in Sham group which could be reversed by valsartan treatment (Fig. 3D).
Affiliation: Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.