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Effects of valsartan on ventricular arrhythmia induced by programmed electrical stimulation in rats with myocardial infarction.

Jiao KL, Li YG, Zhang PP, Chen RH, Yu Y - J. Cell. Mol. Med. (2012)

Bottom Line: Valsartan effectively improved the cardiac function, reduced the prolonged QTc (163.7 ± 3.7 msec. versus 177.8 ± 4.5 msec., P < 0.05) after MI and the incidence of VT or VF evoked by PES (21.1% versus 55%, P < 0.05).The mRNA and protein expressions of Cx43 in BZ were significantly reduced after MI and up-regulated by valsartan.Increased collagen deposition and reduced Cx43 expression in BZ after MI could be partly attenuated by Valsartan.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

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Related in: MedlinePlus

Effects of valsartan on expressions of AT1R and Cx43. The mRNA levels of (A) AT1R and (B) Cx43 were evaluated by the real-time PCR (n = 6). The protein levels of (C) AT1R and (D) Cx43 were analysed by Western blot (n = 7). Proteins loading of each sample in different groups were normalized by Tublin, the house keeping gene. BZ: border zone; NIZ: non-infarct zone. *P < 0.05 versus Sham group; #P < 0.05 versus NIZ; †P < 0.05 versus MI group.
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fig03: Effects of valsartan on expressions of AT1R and Cx43. The mRNA levels of (A) AT1R and (B) Cx43 were evaluated by the real-time PCR (n = 6). The protein levels of (C) AT1R and (D) Cx43 were analysed by Western blot (n = 7). Proteins loading of each sample in different groups were normalized by Tublin, the house keeping gene. BZ: border zone; NIZ: non-infarct zone. *P < 0.05 versus Sham group; #P < 0.05 versus NIZ; †P < 0.05 versus MI group.

Mentions: The mRNA level of Cx43 in BZ and NIZ of MI group was significantly lower than in Sham group (P < 0.05) and the reduction was more significant in BZ than in NIZ; the mRNA level of Cx43 in BZ and NIZ was significantly higher in MI + Val group than in MI group. The protein expression of Cx43 in BZ was significantly reduced in MI group than in Sham group which could be reversed by valsartan treatment (Fig. 3D).


Effects of valsartan on ventricular arrhythmia induced by programmed electrical stimulation in rats with myocardial infarction.

Jiao KL, Li YG, Zhang PP, Chen RH, Yu Y - J. Cell. Mol. Med. (2012)

Effects of valsartan on expressions of AT1R and Cx43. The mRNA levels of (A) AT1R and (B) Cx43 were evaluated by the real-time PCR (n = 6). The protein levels of (C) AT1R and (D) Cx43 were analysed by Western blot (n = 7). Proteins loading of each sample in different groups were normalized by Tublin, the house keeping gene. BZ: border zone; NIZ: non-infarct zone. *P < 0.05 versus Sham group; #P < 0.05 versus NIZ; †P < 0.05 versus MI group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3823086&req=5

fig03: Effects of valsartan on expressions of AT1R and Cx43. The mRNA levels of (A) AT1R and (B) Cx43 were evaluated by the real-time PCR (n = 6). The protein levels of (C) AT1R and (D) Cx43 were analysed by Western blot (n = 7). Proteins loading of each sample in different groups were normalized by Tublin, the house keeping gene. BZ: border zone; NIZ: non-infarct zone. *P < 0.05 versus Sham group; #P < 0.05 versus NIZ; †P < 0.05 versus MI group.
Mentions: The mRNA level of Cx43 in BZ and NIZ of MI group was significantly lower than in Sham group (P < 0.05) and the reduction was more significant in BZ than in NIZ; the mRNA level of Cx43 in BZ and NIZ was significantly higher in MI + Val group than in MI group. The protein expression of Cx43 in BZ was significantly reduced in MI group than in Sham group which could be reversed by valsartan treatment (Fig. 3D).

Bottom Line: Valsartan effectively improved the cardiac function, reduced the prolonged QTc (163.7 ± 3.7 msec. versus 177.8 ± 4.5 msec., P < 0.05) after MI and the incidence of VT or VF evoked by PES (21.1% versus 55%, P < 0.05).The mRNA and protein expressions of Cx43 in BZ were significantly reduced after MI and up-regulated by valsartan.Increased collagen deposition and reduced Cx43 expression in BZ after MI could be partly attenuated by Valsartan.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Show MeSH
Related in: MedlinePlus