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Selection of disease-specific biomarkers by integrating inflammatory mediators with clinical informatics in AECOPD patients: a preliminary study.

Chen H, Song Z, Qian M, Bai C, Wang X - J. Cell. Mol. Med. (2012)

Bottom Line: Chemokine data was compared among different groups and its correlation with DESS scores was performed by SPSS software.Of them, some had significant correlation with DESS scores.Our preliminary study suggested that integration of proteomics with clinical informatics can be a new way to validate and optimize disease-special biomarkers.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

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Plasma levels of interferon γ-induced protein 10 kD (IP-10), granulocyte chemotactic protein 2 (GCP-2), macrophage inflammatory proteins (MIP), macrophage migration inhibitory factor (MIF) and interleukin (IL)-28A and -29 in healthy, patients with stable COPD (sCOPD) and AECOPD patients on days 1, 3 and 7–10. * and ** stand for P values less than 0.05 and 0.01, respectively, as compared with healthy control. † and †† stand for P values less than 0.05 and 0.01, respectively, as compared with sCOPD patients.
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fig02: Plasma levels of interferon γ-induced protein 10 kD (IP-10), granulocyte chemotactic protein 2 (GCP-2), macrophage inflammatory proteins (MIP), macrophage migration inhibitory factor (MIF) and interleukin (IL)-28A and -29 in healthy, patients with stable COPD (sCOPD) and AECOPD patients on days 1, 3 and 7–10. * and ** stand for P values less than 0.05 and 0.01, respectively, as compared with healthy control. † and †† stand for P values less than 0.05 and 0.01, respectively, as compared with sCOPD patients.

Mentions: Of 40 chemokines tested, Eotaxin-3 and NAP-2 in every group was below the minimal value of the detection. Levels of HCC-1, HCC-2 and 6Ckine in sCOPD patients or AECOPD were significantly higher than the healthy (Fig. 1, P < 0.05 or 0.01, respectively), while levels of MIP-3b, IL-17F and IL-31 were significantly altered only in sCOPD patients. Levels of IP-10, IL-28, IL-29, MIF, MIP3a and GCP-2 in sCOPD patients were significantly higher than the healthy or AECOPD patients (Fig. 2, P < 0.05 or 0.01, respectively).


Selection of disease-specific biomarkers by integrating inflammatory mediators with clinical informatics in AECOPD patients: a preliminary study.

Chen H, Song Z, Qian M, Bai C, Wang X - J. Cell. Mol. Med. (2012)

Plasma levels of interferon γ-induced protein 10 kD (IP-10), granulocyte chemotactic protein 2 (GCP-2), macrophage inflammatory proteins (MIP), macrophage migration inhibitory factor (MIF) and interleukin (IL)-28A and -29 in healthy, patients with stable COPD (sCOPD) and AECOPD patients on days 1, 3 and 7–10. * and ** stand for P values less than 0.05 and 0.01, respectively, as compared with healthy control. † and †† stand for P values less than 0.05 and 0.01, respectively, as compared with sCOPD patients.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3823081&req=5

fig02: Plasma levels of interferon γ-induced protein 10 kD (IP-10), granulocyte chemotactic protein 2 (GCP-2), macrophage inflammatory proteins (MIP), macrophage migration inhibitory factor (MIF) and interleukin (IL)-28A and -29 in healthy, patients with stable COPD (sCOPD) and AECOPD patients on days 1, 3 and 7–10. * and ** stand for P values less than 0.05 and 0.01, respectively, as compared with healthy control. † and †† stand for P values less than 0.05 and 0.01, respectively, as compared with sCOPD patients.
Mentions: Of 40 chemokines tested, Eotaxin-3 and NAP-2 in every group was below the minimal value of the detection. Levels of HCC-1, HCC-2 and 6Ckine in sCOPD patients or AECOPD were significantly higher than the healthy (Fig. 1, P < 0.05 or 0.01, respectively), while levels of MIP-3b, IL-17F and IL-31 were significantly altered only in sCOPD patients. Levels of IP-10, IL-28, IL-29, MIF, MIP3a and GCP-2 in sCOPD patients were significantly higher than the healthy or AECOPD patients (Fig. 2, P < 0.05 or 0.01, respectively).

Bottom Line: Chemokine data was compared among different groups and its correlation with DESS scores was performed by SPSS software.Of them, some had significant correlation with DESS scores.Our preliminary study suggested that integration of proteomics with clinical informatics can be a new way to validate and optimize disease-special biomarkers.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Show MeSH
Related in: MedlinePlus