Selection of disease-specific biomarkers by integrating inflammatory mediators with clinical informatics in AECOPD patients: a preliminary study.
Bottom Line: Chemokine data was compared among different groups and its correlation with DESS scores was performed by SPSS software.Of them, some had significant correlation with DESS scores.Our preliminary study suggested that integration of proteomics with clinical informatics can be a new way to validate and optimize disease-special biomarkers.
Affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.Show MeSH
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Mentions: Of 40 chemokines tested, Eotaxin-3 and NAP-2 in every group was below the minimal value of the detection. Levels of HCC-1, HCC-2 and 6Ckine in sCOPD patients or AECOPD were significantly higher than the healthy (Fig. 1, P < 0.05 or 0.01, respectively), while levels of MIP-3b, IL-17F and IL-31 were significantly altered only in sCOPD patients. Levels of IP-10, IL-28, IL-29, MIF, MIP3a and GCP-2 in sCOPD patients were significantly higher than the healthy or AECOPD patients (Fig. 2, P < 0.05 or 0.01, respectively).
Affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.