Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice.
Bottom Line: According to epidemiological studies, type-2 diabetes increases the risk of Alzheimer's disease.Neither high-fat diet nor IGF-2 increased β-amyloid burden in the brain.These findings provide evidence for new regulatory mechanisms that link type-2 diabetes and Alzheimer pathology.
Affiliation: Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland. email@example.comShow MeSH
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Mentions: In addition, insoluble Aβ1–40 (Fig. 5A and B) and Aβ1–42 (Fig. 5C and D) levels were measured from the same protein lysates. Among female mice, Aβ levels did not differ between the genotypes or diet groups. However, IGF-2 χ diet interaction revealed a borderline significance for increased Aβ1–40 levels in A+I+ female mice on TWD [F(1,26) ∇ 4.0, P ∇ 0.06] (Fig. 5A). In contrast, male A+I+ mice on STD or TWD had lower Aβ1–40 [F(1,32) ∇ 5.6, P ∇ 0.03] levels as compared to A+Iw mice on STD or TWD (Fig. 5B). Insoluble Aβ1–42 levels did not differ between the genotypes or diet groups in either female or male mice (Fig. 5C and D). However, male A+I+ mice showed a higher Aβ 42/40 ratio than A+Iw mice (F ∇ 8.6, P ∇ 0.006; Fig. 5F), while neither the IGF-2 transgene nor the diet modulated this ratio in female mice (Fig. 5E).
Affiliation: Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland. firstname.lastname@example.org