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Tissue engineering and regenerative medicine -where do we stand?

Horch RE, Kneser U, Polykandriotis E, Schmidt VJ, Sun J, Arkudas A - J. Cell. Mol. Med. (2012)

Bottom Line: As a typical example in translational medicine, the discovery of a new type of cells called Telocytes that have been described in many organs and have been detected by electron microscopy opens another gate to RM.This article is intended to give an overview over some of the most recent developments and possible applications in RM through the perspective of TE achievements and cellular research.The synthesis of TE with innovative methods of molecular biology and stem-cell technology appears to be very promising.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic and Hand Surgery And Laboratory for Tissue Engineering and Regenerative Medicine, Friedrich Alexander University Erlangen-Nuernberg, Erlangen, Germany. raymund.horch@uk-erlangen.de

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Transmission electron microscopy. (A) Human atrial myocardium. A telocyte (digitally coloured in blue) is located among atrial cardiomyocytes (the atrial granules are obvious). Telopodes are situated in between cardiomyocytes (Tp1, Tp2, Tp4, Tp5), and another telopode (Tp3) with close spatial relation with the blood vessels. The apposition of Tp1 and Tp2 suggests that telocytes are realizing a network, by homo-cellular junctions. (B) 1-yr old mouse subepicardial stem-cell niche. Close relationship in between a telocyte and its telopode with a cardiomyocyte progenitor (the cell containing leptofibrills – ‘zebra-like’ striations – Z). The arrow indicates desmosome – the origin for a future intercalated disc. The telocyte have shedding vesicles (asterisks) – digitally coloured in violet. N – nucleus, m – mitochondria Kindly provided by Prof. L.M. Popescu, National Institute of Pathology, Bucharest, Romania.
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fig05: Transmission electron microscopy. (A) Human atrial myocardium. A telocyte (digitally coloured in blue) is located among atrial cardiomyocytes (the atrial granules are obvious). Telopodes are situated in between cardiomyocytes (Tp1, Tp2, Tp4, Tp5), and another telopode (Tp3) with close spatial relation with the blood vessels. The apposition of Tp1 and Tp2 suggests that telocytes are realizing a network, by homo-cellular junctions. (B) 1-yr old mouse subepicardial stem-cell niche. Close relationship in between a telocyte and its telopode with a cardiomyocyte progenitor (the cell containing leptofibrills – ‘zebra-like’ striations – Z). The arrow indicates desmosome – the origin for a future intercalated disc. The telocyte have shedding vesicles (asterisks) – digitally coloured in violet. N – nucleus, m – mitochondria Kindly provided by Prof. L.M. Popescu, National Institute of Pathology, Bucharest, Romania.

Mentions: Another exciting discovery are telocytes, a new type on interstitial cells, that might well influence RM approaches, especially in the context of cardiac regeneration. The short history of telocytes detection was published in 2010, as a case of serendipity [86]. The existence of these cells was reported within interstitium of many cavitary and non-cavitary organs [87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103], as well as in heart (epicardium [104], myocardium [87,88] and endocardium [105]) (Fig. 5).


Tissue engineering and regenerative medicine -where do we stand?

Horch RE, Kneser U, Polykandriotis E, Schmidt VJ, Sun J, Arkudas A - J. Cell. Mol. Med. (2012)

Transmission electron microscopy. (A) Human atrial myocardium. A telocyte (digitally coloured in blue) is located among atrial cardiomyocytes (the atrial granules are obvious). Telopodes are situated in between cardiomyocytes (Tp1, Tp2, Tp4, Tp5), and another telopode (Tp3) with close spatial relation with the blood vessels. The apposition of Tp1 and Tp2 suggests that telocytes are realizing a network, by homo-cellular junctions. (B) 1-yr old mouse subepicardial stem-cell niche. Close relationship in between a telocyte and its telopode with a cardiomyocyte progenitor (the cell containing leptofibrills – ‘zebra-like’ striations – Z). The arrow indicates desmosome – the origin for a future intercalated disc. The telocyte have shedding vesicles (asterisks) – digitally coloured in violet. N – nucleus, m – mitochondria Kindly provided by Prof. L.M. Popescu, National Institute of Pathology, Bucharest, Romania.
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Related In: Results  -  Collection

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fig05: Transmission electron microscopy. (A) Human atrial myocardium. A telocyte (digitally coloured in blue) is located among atrial cardiomyocytes (the atrial granules are obvious). Telopodes are situated in between cardiomyocytes (Tp1, Tp2, Tp4, Tp5), and another telopode (Tp3) with close spatial relation with the blood vessels. The apposition of Tp1 and Tp2 suggests that telocytes are realizing a network, by homo-cellular junctions. (B) 1-yr old mouse subepicardial stem-cell niche. Close relationship in between a telocyte and its telopode with a cardiomyocyte progenitor (the cell containing leptofibrills – ‘zebra-like’ striations – Z). The arrow indicates desmosome – the origin for a future intercalated disc. The telocyte have shedding vesicles (asterisks) – digitally coloured in violet. N – nucleus, m – mitochondria Kindly provided by Prof. L.M. Popescu, National Institute of Pathology, Bucharest, Romania.
Mentions: Another exciting discovery are telocytes, a new type on interstitial cells, that might well influence RM approaches, especially in the context of cardiac regeneration. The short history of telocytes detection was published in 2010, as a case of serendipity [86]. The existence of these cells was reported within interstitium of many cavitary and non-cavitary organs [87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103], as well as in heart (epicardium [104], myocardium [87,88] and endocardium [105]) (Fig. 5).

Bottom Line: As a typical example in translational medicine, the discovery of a new type of cells called Telocytes that have been described in many organs and have been detected by electron microscopy opens another gate to RM.This article is intended to give an overview over some of the most recent developments and possible applications in RM through the perspective of TE achievements and cellular research.The synthesis of TE with innovative methods of molecular biology and stem-cell technology appears to be very promising.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic and Hand Surgery And Laboratory for Tissue Engineering and Regenerative Medicine, Friedrich Alexander University Erlangen-Nuernberg, Erlangen, Germany. raymund.horch@uk-erlangen.de

Show MeSH
Related in: MedlinePlus