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The capsaicin 8% patch for neuropathic pain in clinical practice: a retrospective analysis.

Wagner T, Poole C, Roth-Daniek A - Pain Med (2013)

Bottom Line: Among the 37 responders (those exhibiting ≥30% reduction in NPRS score from baseline to Weeks 1-8), the median time to re-treatment was 125 days.Following treatment, there was a significant (P < 0.001) 54% reduction in the mean number of prescribed concomitant NP medications taken by patients.This analysis demonstrates that in clinical practice, the capsaicin 8% patch provides rapid and sustained pain reductions in patients with a variety of PNP conditions and a significant reduction in prescribed concomitant NP medications.

View Article: PubMed Central - PubMed

Affiliation: Medizinisches Zentrum Städteregion Aachen, Würselen, Germany. till.wagner@mz-ac.de

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Changes in the use of prescribed concomitant peripheral neuropathic pain (PNP) medications following the first treatment with the capsaicin 8% patch. Changes in the use of (A) opioids, (B) anticonvulsants, and (C) antidepressants. Percentages add up to >100% due to rounding errors.
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fig04: Changes in the use of prescribed concomitant peripheral neuropathic pain (PNP) medications following the first treatment with the capsaicin 8% patch. Changes in the use of (A) opioids, (B) anticonvulsants, and (C) antidepressants. Percentages add up to >100% due to rounding errors.

Mentions: There was a significant (P < 0.001) reduction in the prescribed concomitant NP medication (opioids, anticonvulsants, or antidepressants) taken by all patients, and those classed as responders, following treatment with the capsaicin 8% patch (Table 2). At the time of capsaicin 8% patch treatment, patients took a mean of 1.37 types of medication for their NP, but following a single application of the capsaicin 8% patch there was a 54% reduction in the mean number of medications taken by each patient (Table 2). Moreover, among patients previously receiving opioids, anticonvulsants, or antidepressants, more than half discontinued this medication, and a further 18%, 16%, and 11%, respectively, reduced their daily dose (Figure 4).


The capsaicin 8% patch for neuropathic pain in clinical practice: a retrospective analysis.

Wagner T, Poole C, Roth-Daniek A - Pain Med (2013)

Changes in the use of prescribed concomitant peripheral neuropathic pain (PNP) medications following the first treatment with the capsaicin 8% patch. Changes in the use of (A) opioids, (B) anticonvulsants, and (C) antidepressants. Percentages add up to >100% due to rounding errors.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3823063&req=5

fig04: Changes in the use of prescribed concomitant peripheral neuropathic pain (PNP) medications following the first treatment with the capsaicin 8% patch. Changes in the use of (A) opioids, (B) anticonvulsants, and (C) antidepressants. Percentages add up to >100% due to rounding errors.
Mentions: There was a significant (P < 0.001) reduction in the prescribed concomitant NP medication (opioids, anticonvulsants, or antidepressants) taken by all patients, and those classed as responders, following treatment with the capsaicin 8% patch (Table 2). At the time of capsaicin 8% patch treatment, patients took a mean of 1.37 types of medication for their NP, but following a single application of the capsaicin 8% patch there was a 54% reduction in the mean number of medications taken by each patient (Table 2). Moreover, among patients previously receiving opioids, anticonvulsants, or antidepressants, more than half discontinued this medication, and a further 18%, 16%, and 11%, respectively, reduced their daily dose (Figure 4).

Bottom Line: Among the 37 responders (those exhibiting ≥30% reduction in NPRS score from baseline to Weeks 1-8), the median time to re-treatment was 125 days.Following treatment, there was a significant (P < 0.001) 54% reduction in the mean number of prescribed concomitant NP medications taken by patients.This analysis demonstrates that in clinical practice, the capsaicin 8% patch provides rapid and sustained pain reductions in patients with a variety of PNP conditions and a significant reduction in prescribed concomitant NP medications.

View Article: PubMed Central - PubMed

Affiliation: Medizinisches Zentrum Städteregion Aachen, Würselen, Germany. till.wagner@mz-ac.de

Show MeSH
Related in: MedlinePlus