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Advances in microRNAs: implications for immunity and inflammatory diseases.

Sonkoly E, Pivarcsi A - J. Cell. Mol. Med. (2009)

Bottom Line: Since their discovery in 1993 and the introduction of the term microRNA in 2001, it has become evident that microRNAs (miRNAs) involved in many biological processes, including development, differentiation, proliferation and apoptosis.The function of miRNA the control of protein production in cells by sequence-specific targeting of mRNAs for translational repression or mRNA degradati Interestingly, immune genes are apparently preferentially targeted by miRNAs compared to the average of the human genome, indicat the significance of miRNA-mediated regulation for normal immune responses.Here, we review what is known about the role of miRN in the pathogenesis of immune-related diseases such as chronic inflammatory skin diseases, autoimmunity and viral infections.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Unit of Dermatology and Venerology, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. eniko.sonkoly@ki.se

ABSTRACT
Since their discovery in 1993 and the introduction of the term microRNA in 2001, it has become evident that microRNAs (miRNAs) involved in many biological processes, including development, differentiation, proliferation and apoptosis. The function of miRNA the control of protein production in cells by sequence-specific targeting of mRNAs for translational repression or mRNA degradati Interestingly, immune genes are apparently preferentially targeted by miRNAs compared to the average of the human genome, indicat the significance of miRNA-mediated regulation for normal immune responses. Here, we review what is known about the role of miRN in the pathogenesis of immune-related diseases such as chronic inflammatory skin diseases, autoimmunity and viral infections.

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Related in: MedlinePlus

The number of microRNA publications each year from 1993 to present based on search for scientific articles by the keyword ‘microRNA’. Note that the term ‘microRNA’ was introduced in 2001, and publications before the introduction of the official term were retrieved by manual search for articles about lin-4 and let-7 the ‘prototype’ miRNAs that were described first. Source: NCBI PubMed. *, as of July 2008.
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fig02: The number of microRNA publications each year from 1993 to present based on search for scientific articles by the keyword ‘microRNA’. Note that the term ‘microRNA’ was introduced in 2001, and publications before the introduction of the official term were retrieved by manual search for articles about lin-4 and let-7 the ‘prototype’ miRNAs that were described first. Source: NCBI PubMed. *, as of July 2008.

Mentions: Since the discovery of miRNAs, the number of publications about miRNAs is increasing exponentially (Fig. 2) and significant progress has been made in dissection of biogenesis and functions of miRNAs. To date, more than 600 individual miRNAs have been identified in the human genome, which are estimated to regulate the vast majority of protein coding RNAs (mRNAs) and each mRNA is likely to be regulated by several miRNAs simultaneously [7, 8]. In total, miRNAs my comprise 5% of all human genes making them the most abundant class of regulators. Experimental evidence suggested that most miRNAs are present at very high steady-state levels – more than 1000 molecules per cell, with some exceeding 50,000 molecules per cell [9].


Advances in microRNAs: implications for immunity and inflammatory diseases.

Sonkoly E, Pivarcsi A - J. Cell. Mol. Med. (2009)

The number of microRNA publications each year from 1993 to present based on search for scientific articles by the keyword ‘microRNA’. Note that the term ‘microRNA’ was introduced in 2001, and publications before the introduction of the official term were retrieved by manual search for articles about lin-4 and let-7 the ‘prototype’ miRNAs that were described first. Source: NCBI PubMed. *, as of July 2008.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3823034&req=5

fig02: The number of microRNA publications each year from 1993 to present based on search for scientific articles by the keyword ‘microRNA’. Note that the term ‘microRNA’ was introduced in 2001, and publications before the introduction of the official term were retrieved by manual search for articles about lin-4 and let-7 the ‘prototype’ miRNAs that were described first. Source: NCBI PubMed. *, as of July 2008.
Mentions: Since the discovery of miRNAs, the number of publications about miRNAs is increasing exponentially (Fig. 2) and significant progress has been made in dissection of biogenesis and functions of miRNAs. To date, more than 600 individual miRNAs have been identified in the human genome, which are estimated to regulate the vast majority of protein coding RNAs (mRNAs) and each mRNA is likely to be regulated by several miRNAs simultaneously [7, 8]. In total, miRNAs my comprise 5% of all human genes making them the most abundant class of regulators. Experimental evidence suggested that most miRNAs are present at very high steady-state levels – more than 1000 molecules per cell, with some exceeding 50,000 molecules per cell [9].

Bottom Line: Since their discovery in 1993 and the introduction of the term microRNA in 2001, it has become evident that microRNAs (miRNAs) involved in many biological processes, including development, differentiation, proliferation and apoptosis.The function of miRNA the control of protein production in cells by sequence-specific targeting of mRNAs for translational repression or mRNA degradati Interestingly, immune genes are apparently preferentially targeted by miRNAs compared to the average of the human genome, indicat the significance of miRNA-mediated regulation for normal immune responses.Here, we review what is known about the role of miRN in the pathogenesis of immune-related diseases such as chronic inflammatory skin diseases, autoimmunity and viral infections.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Unit of Dermatology and Venerology, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. eniko.sonkoly@ki.se

ABSTRACT
Since their discovery in 1993 and the introduction of the term microRNA in 2001, it has become evident that microRNAs (miRNAs) involved in many biological processes, including development, differentiation, proliferation and apoptosis. The function of miRNA the control of protein production in cells by sequence-specific targeting of mRNAs for translational repression or mRNA degradati Interestingly, immune genes are apparently preferentially targeted by miRNAs compared to the average of the human genome, indicat the significance of miRNA-mediated regulation for normal immune responses. Here, we review what is known about the role of miRN in the pathogenesis of immune-related diseases such as chronic inflammatory skin diseases, autoimmunity and viral infections.

Show MeSH
Related in: MedlinePlus