The therapeutic effect of rosuvastatin on cardiac remodelling from hypertrophy to fibrosis during the end-stage hypertension in rats.
Bottom Line: Old-aged SHR developed end-stage hypertensive heart disease characterized by significant enhancement of HW/BW%, LVAWd and LVPWd, and decreased LVEF and LVFS, accompanied by cardiomyocytes enlargement and fibrosis along with activation of foetal gene programme.Cardiac apoptosis increased significantly during the transition process.Rosuvastatin effectively attenuated the structural changes by reversing the signaling transductions involved.
Affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.Show MeSH
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Mentions: Masson Trichrome staining clearly showed increased interstitial collagen and fibrin accumulation in SHR controls compared with WKY, 5.08 ± 1.88% versus 1.22 ± 0.51% (P < 0.05). The extracellular matrix changes were significantly reversed in SHR + LD and SHR + HD by 49.8% and 62.6%, respectively, but without significant differences between them, 2.55 ± 0.25% and 1.90 ± 0.47% versus 5.08 ± 1.88% (P < 0.05) (Fig. 4).
Affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.