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The therapeutic effect of rosuvastatin on cardiac remodelling from hypertrophy to fibrosis during the end-stage hypertension in rats.

Zhang WB, Du QJ, Li H, Sun AJ, Qiu ZH, Wu CN, Zhao G, Gong H, Hu K, Zou YZ, Ge JB - J. Cell. Mol. Med. (2012)

Bottom Line: Old-aged SHR developed end-stage hypertensive heart disease characterized by significant enhancement of HW/BW%, LVAWd and LVPWd, and decreased LVEF and LVFS, accompanied by cardiomyocytes enlargement and fibrosis along with activation of foetal gene programme.Cardiac apoptosis increased significantly during the transition process.Rosuvastatin effectively attenuated the structural changes by reversing the signaling transductions involved.

View Article: PubMed Central - PubMed

Affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

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Related in: MedlinePlus

Masson's trichrome stain of hearts of WKY controls, SHR controls, SHR + LD and SHR + HD, Blue = fibrous collagen, red = myocytes. (A) the comparative fibrosis of WKY controls; (B) SHR controls showing an increasing amount of collagen deposition compared with WKY controls (P < 0.05); (C & D). SHR + LD and SHR + HD, less collagen accumulation compared with SHR controls (P < 0.05); representative histological sections; (E) quantitative analysis of fibrosis in the four groups by the ratio of the fibrosis area to the whole. Values, mean ± SED; n = 3–4; *P < 0.05 versus WKY controls; #P < 0.05 versus SHR controls.
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fig04: Masson's trichrome stain of hearts of WKY controls, SHR controls, SHR + LD and SHR + HD, Blue = fibrous collagen, red = myocytes. (A) the comparative fibrosis of WKY controls; (B) SHR controls showing an increasing amount of collagen deposition compared with WKY controls (P < 0.05); (C & D). SHR + LD and SHR + HD, less collagen accumulation compared with SHR controls (P < 0.05); representative histological sections; (E) quantitative analysis of fibrosis in the four groups by the ratio of the fibrosis area to the whole. Values, mean ± SED; n = 3–4; *P < 0.05 versus WKY controls; #P < 0.05 versus SHR controls.

Mentions: Masson Trichrome staining clearly showed increased interstitial collagen and fibrin accumulation in SHR controls compared with WKY, 5.08 ± 1.88% versus 1.22 ± 0.51% (P < 0.05). The extracellular matrix changes were significantly reversed in SHR + LD and SHR + HD by 49.8% and 62.6%, respectively, but without significant differences between them, 2.55 ± 0.25% and 1.90 ± 0.47% versus 5.08 ± 1.88% (P < 0.05) (Fig. 4).


The therapeutic effect of rosuvastatin on cardiac remodelling from hypertrophy to fibrosis during the end-stage hypertension in rats.

Zhang WB, Du QJ, Li H, Sun AJ, Qiu ZH, Wu CN, Zhao G, Gong H, Hu K, Zou YZ, Ge JB - J. Cell. Mol. Med. (2012)

Masson's trichrome stain of hearts of WKY controls, SHR controls, SHR + LD and SHR + HD, Blue = fibrous collagen, red = myocytes. (A) the comparative fibrosis of WKY controls; (B) SHR controls showing an increasing amount of collagen deposition compared with WKY controls (P < 0.05); (C & D). SHR + LD and SHR + HD, less collagen accumulation compared with SHR controls (P < 0.05); representative histological sections; (E) quantitative analysis of fibrosis in the four groups by the ratio of the fibrosis area to the whole. Values, mean ± SED; n = 3–4; *P < 0.05 versus WKY controls; #P < 0.05 versus SHR controls.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3822992&req=5

fig04: Masson's trichrome stain of hearts of WKY controls, SHR controls, SHR + LD and SHR + HD, Blue = fibrous collagen, red = myocytes. (A) the comparative fibrosis of WKY controls; (B) SHR controls showing an increasing amount of collagen deposition compared with WKY controls (P < 0.05); (C & D). SHR + LD and SHR + HD, less collagen accumulation compared with SHR controls (P < 0.05); representative histological sections; (E) quantitative analysis of fibrosis in the four groups by the ratio of the fibrosis area to the whole. Values, mean ± SED; n = 3–4; *P < 0.05 versus WKY controls; #P < 0.05 versus SHR controls.
Mentions: Masson Trichrome staining clearly showed increased interstitial collagen and fibrin accumulation in SHR controls compared with WKY, 5.08 ± 1.88% versus 1.22 ± 0.51% (P < 0.05). The extracellular matrix changes were significantly reversed in SHR + LD and SHR + HD by 49.8% and 62.6%, respectively, but without significant differences between them, 2.55 ± 0.25% and 1.90 ± 0.47% versus 5.08 ± 1.88% (P < 0.05) (Fig. 4).

Bottom Line: Old-aged SHR developed end-stage hypertensive heart disease characterized by significant enhancement of HW/BW%, LVAWd and LVPWd, and decreased LVEF and LVFS, accompanied by cardiomyocytes enlargement and fibrosis along with activation of foetal gene programme.Cardiac apoptosis increased significantly during the transition process.Rosuvastatin effectively attenuated the structural changes by reversing the signaling transductions involved.

View Article: PubMed Central - PubMed

Affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

Show MeSH
Related in: MedlinePlus