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Identification of telocytes in the upper lamina propria of the human urinary tract.

Gevaert T, De Vos R, Van Der Aa F, Joniau S, van den Oord J, Roskams T, De Ridder D - J. Cell. Mol. Med. (2012)

Bottom Line: Tissue was obtained from normal areas in nephrectomy, cystectomy and prostatectomy specimens, and processed for morphology, immunohistochemistry and electron microscopy.The ULP IC in renal pelvis, ureter and urethra had a similar ultrastructural phenotype, which differed somehow from that of bladder IC, that is, thinner and longer cytoplasmic processes, no peripheral actin filaments and presence of dense core granules and microtubules.The functional relevance of ULP telocytes in the urinary tract remains to be elucidated, and ER and PR might therefore be promising pharmacological research targets.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, KU Leuven, University Hospitals Gasthuisberg, Leuven, Belgium. Thomas.Gevaert@med.kuleuven.be

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The immunohistochemical phenotype of upper lamina propria (ULP) telocytes in human renal pelvis: immunoreactivity for vimentin, oestrogen receptor (ER; 67%), progesterone receptor (70%) and caveolin-1 (70%); negativity for α-smooth muscle actin (sma), CD34 and caveolin-1. Vimentin is also expressed on blood vessels. α-sma stains the perivascular smooth muscle cells. Caveolin-1 and CD34 are expressed on blood vessel endothelium. Note the organization of telocytes in 2–3 densely packed cell layers, as illustrated by ER stains. Double arrows mark the ULP telocyte layer. Scale bars = 50 μm. U: urothelial area.
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fig04: The immunohistochemical phenotype of upper lamina propria (ULP) telocytes in human renal pelvis: immunoreactivity for vimentin, oestrogen receptor (ER; 67%), progesterone receptor (70%) and caveolin-1 (70%); negativity for α-smooth muscle actin (sma), CD34 and caveolin-1. Vimentin is also expressed on blood vessels. α-sma stains the perivascular smooth muscle cells. Caveolin-1 and CD34 are expressed on blood vessel endothelium. Note the organization of telocytes in 2–3 densely packed cell layers, as illustrated by ER stains. Double arrows mark the ULP telocyte layer. Scale bars = 50 μm. U: urothelial area.

Mentions: Immunohistochemical characterization of renal pelvis ULP IC revealed the expression of vimentin (Fig. 4). The majority of ULP IC expressed ER (67%), PR (70%) and caveolin-1 (70%; Table 3 and Fig. 4). There was no expression of α-sma, CD34 (Fig. 4), desmin, CD10, VEGF, synaptophysin, c-kit, neurofilament and S100 (not shown).


Identification of telocytes in the upper lamina propria of the human urinary tract.

Gevaert T, De Vos R, Van Der Aa F, Joniau S, van den Oord J, Roskams T, De Ridder D - J. Cell. Mol. Med. (2012)

The immunohistochemical phenotype of upper lamina propria (ULP) telocytes in human renal pelvis: immunoreactivity for vimentin, oestrogen receptor (ER; 67%), progesterone receptor (70%) and caveolin-1 (70%); negativity for α-smooth muscle actin (sma), CD34 and caveolin-1. Vimentin is also expressed on blood vessels. α-sma stains the perivascular smooth muscle cells. Caveolin-1 and CD34 are expressed on blood vessel endothelium. Note the organization of telocytes in 2–3 densely packed cell layers, as illustrated by ER stains. Double arrows mark the ULP telocyte layer. Scale bars = 50 μm. U: urothelial area.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3822978&req=5

fig04: The immunohistochemical phenotype of upper lamina propria (ULP) telocytes in human renal pelvis: immunoreactivity for vimentin, oestrogen receptor (ER; 67%), progesterone receptor (70%) and caveolin-1 (70%); negativity for α-smooth muscle actin (sma), CD34 and caveolin-1. Vimentin is also expressed on blood vessels. α-sma stains the perivascular smooth muscle cells. Caveolin-1 and CD34 are expressed on blood vessel endothelium. Note the organization of telocytes in 2–3 densely packed cell layers, as illustrated by ER stains. Double arrows mark the ULP telocyte layer. Scale bars = 50 μm. U: urothelial area.
Mentions: Immunohistochemical characterization of renal pelvis ULP IC revealed the expression of vimentin (Fig. 4). The majority of ULP IC expressed ER (67%), PR (70%) and caveolin-1 (70%; Table 3 and Fig. 4). There was no expression of α-sma, CD34 (Fig. 4), desmin, CD10, VEGF, synaptophysin, c-kit, neurofilament and S100 (not shown).

Bottom Line: Tissue was obtained from normal areas in nephrectomy, cystectomy and prostatectomy specimens, and processed for morphology, immunohistochemistry and electron microscopy.The ULP IC in renal pelvis, ureter and urethra had a similar ultrastructural phenotype, which differed somehow from that of bladder IC, that is, thinner and longer cytoplasmic processes, no peripheral actin filaments and presence of dense core granules and microtubules.The functional relevance of ULP telocytes in the urinary tract remains to be elucidated, and ER and PR might therefore be promising pharmacological research targets.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, KU Leuven, University Hospitals Gasthuisberg, Leuven, Belgium. Thomas.Gevaert@med.kuleuven.be

Show MeSH
Related in: MedlinePlus