Identification of telocytes in the upper lamina propria of the human urinary tract.
Bottom Line: Tissue was obtained from normal areas in nephrectomy, cystectomy and prostatectomy specimens, and processed for morphology, immunohistochemistry and electron microscopy.The ULP IC in renal pelvis, ureter and urethra had a similar ultrastructural phenotype, which differed somehow from that of bladder IC, that is, thinner and longer cytoplasmic processes, no peripheral actin filaments and presence of dense core granules and microtubules.The functional relevance of ULP telocytes in the urinary tract remains to be elucidated, and ER and PR might therefore be promising pharmacological research targets.
Affiliation: Department of Urology, KU Leuven, University Hospitals Gasthuisberg, Leuven, Belgium. Thomas.Gevaert@med.kuleuven.beShow MeSH
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Mentions: Immunohistochemical characterization of renal pelvis ULP IC revealed the expression of vimentin (Fig. 4). The majority of ULP IC expressed ER (67%), PR (70%) and caveolin-1 (70%; Table 3 and Fig. 4). There was no expression of α-sma, CD34 (Fig. 4), desmin, CD10, VEGF, synaptophysin, c-kit, neurofilament and S100 (not shown).
Affiliation: Department of Urology, KU Leuven, University Hospitals Gasthuisberg, Leuven, Belgium. Thomas.Gevaert@med.kuleuven.be