Limits...
Endothelial progenitor cells are integrated in newly formed capillaries and alter adjacent fibrovascular tissue after subcutaneous implantation in a fibrin matrix.

Bleiziffer O, Hammon M, Naschberger E, Lipnik K, Arkudas A, Rath S, Pryymachuk G, Beier JP, Stürzl M, Horch RE, Kneser U - J. Cell. Mol. Med. (2011)

Bottom Line: Transplanted cells were also found in the intermuscular septa.Presence of cells in the fibrin clot lead to thicker granulation tissue and an increased blood vessel diameter compared to cell-free controls.EPC may hold promise to modulate blood vessel formation in bioartificial matrices.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic and Hand Surgery, University Hospital Erlangen, Erlangen, Germany.

Show MeSH

Related in: MedlinePlus

Morphometric analysis of number of blood vessels. Grey bar = fibrin; black bar = fibrin + EPC. #P < 0.05 versus Fibrin at day 7; **P < 0.05 versus Fibrin at day 3. N= 6 constructs per group and time-point.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3822956&req=5

fig04: Morphometric analysis of number of blood vessels. Grey bar = fibrin; black bar = fibrin + EPC. #P < 0.05 versus Fibrin at day 7; **P < 0.05 versus Fibrin at day 3. N= 6 constructs per group and time-point.

Mentions: The total number of blood vessels counted in fibrovascular tissue adjacent to the matrices of lectin stained cross-sections was significantly increased after 3 and 7 days when T17b were present in the fibrin clot. At day 14, there was no significant difference in number of blood vessels (Fig. 4).


Endothelial progenitor cells are integrated in newly formed capillaries and alter adjacent fibrovascular tissue after subcutaneous implantation in a fibrin matrix.

Bleiziffer O, Hammon M, Naschberger E, Lipnik K, Arkudas A, Rath S, Pryymachuk G, Beier JP, Stürzl M, Horch RE, Kneser U - J. Cell. Mol. Med. (2011)

Morphometric analysis of number of blood vessels. Grey bar = fibrin; black bar = fibrin + EPC. #P < 0.05 versus Fibrin at day 7; **P < 0.05 versus Fibrin at day 3. N= 6 constructs per group and time-point.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3822956&req=5

fig04: Morphometric analysis of number of blood vessels. Grey bar = fibrin; black bar = fibrin + EPC. #P < 0.05 versus Fibrin at day 7; **P < 0.05 versus Fibrin at day 3. N= 6 constructs per group and time-point.
Mentions: The total number of blood vessels counted in fibrovascular tissue adjacent to the matrices of lectin stained cross-sections was significantly increased after 3 and 7 days when T17b were present in the fibrin clot. At day 14, there was no significant difference in number of blood vessels (Fig. 4).

Bottom Line: Transplanted cells were also found in the intermuscular septa.Presence of cells in the fibrin clot lead to thicker granulation tissue and an increased blood vessel diameter compared to cell-free controls.EPC may hold promise to modulate blood vessel formation in bioartificial matrices.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic and Hand Surgery, University Hospital Erlangen, Erlangen, Germany.

Show MeSH
Related in: MedlinePlus