Endothelial progenitor cells are integrated in newly formed capillaries and alter adjacent fibrovascular tissue after subcutaneous implantation in a fibrin matrix.
Bottom Line: Transplanted cells were also found in the intermuscular septa.Presence of cells in the fibrin clot lead to thicker granulation tissue and an increased blood vessel diameter compared to cell-free controls.EPC may hold promise to modulate blood vessel formation in bioartificial matrices.
Affiliation: Department of Plastic and Hand Surgery, University Hospital Erlangen, Erlangen, Germany.Show MeSH
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Mentions: The total number of blood vessels counted in fibrovascular tissue adjacent to the matrices of lectin stained cross-sections was significantly increased after 3 and 7 days when T17b were present in the fibrin clot. At day 14, there was no significant difference in number of blood vessels (Fig. 4).
Affiliation: Department of Plastic and Hand Surgery, University Hospital Erlangen, Erlangen, Germany.