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Endothelial progenitor cells are integrated in newly formed capillaries and alter adjacent fibrovascular tissue after subcutaneous implantation in a fibrin matrix.

Bleiziffer O, Hammon M, Naschberger E, Lipnik K, Arkudas A, Rath S, Pryymachuk G, Beier JP, Stürzl M, Horch RE, Kneser U - J. Cell. Mol. Med. (2011)

Bottom Line: Transplanted cells were also found in the intermuscular septa.Presence of cells in the fibrin clot lead to thicker granulation tissue and an increased blood vessel diameter compared to cell-free controls.EPC may hold promise to modulate blood vessel formation in bioartificial matrices.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic and Hand Surgery, University Hospital Erlangen, Erlangen, Germany.

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Morphometric analysis of fibrovascular tissue thickness. Grey bar = fibrin; black bar = fibrin + EPC. *P < 0.05 versus Fibrin at day 14; #P < 0.05 versus Fibrin at day 7; **P < 0.05 versus Fibrin at day 3. N= 6 constructs per group and time-point.
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fig03: Morphometric analysis of fibrovascular tissue thickness. Grey bar = fibrin; black bar = fibrin + EPC. *P < 0.05 versus Fibrin at day 14; #P < 0.05 versus Fibrin at day 7; **P < 0.05 versus Fibrin at day 3. N= 6 constructs per group and time-point.

Mentions: The use of EPC significantly increased height of fibrovascular tissue at 3 days, 7 days as well as 14 days compared to EPC-free controls (Fig. 3).


Endothelial progenitor cells are integrated in newly formed capillaries and alter adjacent fibrovascular tissue after subcutaneous implantation in a fibrin matrix.

Bleiziffer O, Hammon M, Naschberger E, Lipnik K, Arkudas A, Rath S, Pryymachuk G, Beier JP, Stürzl M, Horch RE, Kneser U - J. Cell. Mol. Med. (2011)

Morphometric analysis of fibrovascular tissue thickness. Grey bar = fibrin; black bar = fibrin + EPC. *P < 0.05 versus Fibrin at day 14; #P < 0.05 versus Fibrin at day 7; **P < 0.05 versus Fibrin at day 3. N= 6 constructs per group and time-point.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3822956&req=5

fig03: Morphometric analysis of fibrovascular tissue thickness. Grey bar = fibrin; black bar = fibrin + EPC. *P < 0.05 versus Fibrin at day 14; #P < 0.05 versus Fibrin at day 7; **P < 0.05 versus Fibrin at day 3. N= 6 constructs per group and time-point.
Mentions: The use of EPC significantly increased height of fibrovascular tissue at 3 days, 7 days as well as 14 days compared to EPC-free controls (Fig. 3).

Bottom Line: Transplanted cells were also found in the intermuscular septa.Presence of cells in the fibrin clot lead to thicker granulation tissue and an increased blood vessel diameter compared to cell-free controls.EPC may hold promise to modulate blood vessel formation in bioartificial matrices.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic and Hand Surgery, University Hospital Erlangen, Erlangen, Germany.

Show MeSH
Related in: MedlinePlus