NK receptors, Substance P, Ano1 expression and ultrastructural features of the muscle coat in Cav-1(-/-) mouse ileum.
Bottom Line: ICC were also labelled with c-Kit and tachykinergic neurons with Substance P (SP).Under TEM: (i) ICC, SMC and telocytes lacked typical caveolae but had few and large flask-shaped vesicles we called large-sized caveolae; (ii) SMC and ICC contained an extraordinary high number of mitochondria, (iii) neurons were unchanged.Loss of Ano-1 expression, decrease of SP content and consequently overexpression of NK receptors suggest that all these molecules are Cav-1-associated proteins.
Affiliation: Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Florence, Italy.Show MeSH
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Mentions: Cav-1 immunoreactivity (IR) in controls appeared as small bars distributed along the plasma membrane on the entire cell contour (Fig. 1A). In the sections from Cav-1−/− mice labelled with fluorescent antibodies, this positivity was not appreciable, whereas in those labelled for bright field microscopy, Cav-1-positivity could still be detected although at a very low intensity (Fig. 1B).
Affiliation: Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Florence, Italy.