Catalase activity prevents exercise-induced up-regulation of vasoprotective proteins in venous tissue.
Bottom Line: Physical activity induces favourable changes of arterial gene expression and protein activity, although little is known about its effect in venous tissue.Both training protocols similarly increased relative heart weight and resulted in up-regulation of aortic and myocardial eNOS.Furthermore, therapeutic inhibition of vascular catalase might improve pulmonary rehabilitation.
Affiliation: Institute for Pharmacology and Clinical Pharmacology, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany.Show MeSH
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Mentions: According to the results of our previous investigations [14, 20] we determined catalase protein expression levels in vena cava and lung in comparison to aorta and myocardium. In sedentary mice, we found a 4.5-fold higher catalase expression in vena cava compared to aorta and after voluntary running this difference increased to 10.5-fold (Fig. 7). Likewise, in sedentary mice we found a 2.9-fold higher catalase expression in lung tissue compared to aorta and after voluntary running this difference increased to 6.9-fold (Fig. 7). In accordance, catalase activity was higher in lung tissue than in aorta (Fig. 7D). These data suggest that high catalase activity in vena cava and lung tissue compared to aorta reduces the steady state level of venous hydrogen peroxide which in turn may impair exercise-induced up-regulation of eNOS expression.
Affiliation: Institute for Pharmacology and Clinical Pharmacology, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany.