Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis.
Bottom Line: Higher resolution images provided the following information: (a) the intercellular space between the abluminal face of endothelium and its surrounding TCs is frequently less than 50 nm; (b) TCs establish multiple direct nanocontacts with endothelial cells, where the extracellular space seems obliterated; such nanocontacts have a length of 0.4-1.5 μm; (c) the absence of basal membrane on the abluminal face of endothelial cell.Besides the physical contacts (either nanoscopic or microscopic) TCs presumably contribute to neo-angiognesis via paracrine secretion (as shown by immunocytochemistry for VEGF or NOS2).Last but not least, TCs contain measurable quantities of angiogenic microRNAs (e.g. let-7e, 10a, 21, 27b, 100, 126-3p, 130a, 143, 155, 503).
Affiliation: Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.Show MeSH
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Mentions: Thirty days after the LADC ligation, a process of recovering characterizes the border zone of the myocardial infarction (Fig. 4). CMs begin to have normal ultrastructural appearance. In the interstitium, the number of TCs is clearly increased in comparison with normal myocardium. TCs/Tps have close spatial relationships with blood capillaries. However, the distances separating the Tps and abluminal front of endothelial cells and Tps are different for capillary of neo-formation (e.g. capillary-1 in Fig. 4) versus preexisting capillaries (e.g. capillary-2 in Fig. 4). Digitally measurements of the nanoscopic and microscopic distances resulted in the following results:
Affiliation: Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.