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Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis.

Manole CG, Cismaşiu V, Gherghiceanu M, Popescu LM - J. Cell. Mol. Med. (2011)

Bottom Line: Higher resolution images provided the following information: (a) the intercellular space between the abluminal face of endothelium and its surrounding TCs is frequently less than 50 nm; (b) TCs establish multiple direct nanocontacts with endothelial cells, where the extracellular space seems obliterated; such nanocontacts have a length of 0.4-1.5 μm; (c) the absence of basal membrane on the abluminal face of endothelial cell.Besides the physical contacts (either nanoscopic or microscopic) TCs presumably contribute to neo-angiognesis via paracrine secretion (as shown by immunocytochemistry for VEGF or NOS2).Last but not least, TCs contain measurable quantities of angiogenic microRNAs (e.g. let-7e, 10a, 21, 27b, 100, 126-3p, 130a, 143, 155, 503).

View Article: PubMed Central - PubMed

Affiliation: Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

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Rat experimental myocardial infarction. Border zone: 30-day-old. Transmission electron microscopy. A telopode (Tp - blue colour) is located between three new-formed capillaries (cap). At the level of capillary A, basal lamina and fragments of pericytes (asterisks) are visible. The capillary endothelium (brown colour) has many vesicles of transcytosis. Note the alternation of podoms (containing mitochondria, endoplasmic reticulum and caveolae) and podomers (thin segments) – arrows.
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fig10: Rat experimental myocardial infarction. Border zone: 30-day-old. Transmission electron microscopy. A telopode (Tp - blue colour) is located between three new-formed capillaries (cap). At the level of capillary A, basal lamina and fragments of pericytes (asterisks) are visible. The capillary endothelium (brown colour) has many vesicles of transcytosis. Note the alternation of podoms (containing mitochondria, endoplasmic reticulum and caveolae) and podomers (thin segments) – arrows.

Mentions: For underlining the involvement of TC in angiogenesis, Figures 9 and 10 show the strategic positions of the Tps either among new-formed blood vessels (Fig. 9), or surrounding them (Fig. 10). The new-formed blood vessels have typical tall endothelial cells with numerous organelles and a narrow and anfractuous lumen (Figs 11 and 12). The endothelium has many transcytosis vesicles.


Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis.

Manole CG, Cismaşiu V, Gherghiceanu M, Popescu LM - J. Cell. Mol. Med. (2011)

Rat experimental myocardial infarction. Border zone: 30-day-old. Transmission electron microscopy. A telopode (Tp - blue colour) is located between three new-formed capillaries (cap). At the level of capillary A, basal lamina and fragments of pericytes (asterisks) are visible. The capillary endothelium (brown colour) has many vesicles of transcytosis. Note the alternation of podoms (containing mitochondria, endoplasmic reticulum and caveolae) and podomers (thin segments) – arrows.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3822940&req=5

fig10: Rat experimental myocardial infarction. Border zone: 30-day-old. Transmission electron microscopy. A telopode (Tp - blue colour) is located between three new-formed capillaries (cap). At the level of capillary A, basal lamina and fragments of pericytes (asterisks) are visible. The capillary endothelium (brown colour) has many vesicles of transcytosis. Note the alternation of podoms (containing mitochondria, endoplasmic reticulum and caveolae) and podomers (thin segments) – arrows.
Mentions: For underlining the involvement of TC in angiogenesis, Figures 9 and 10 show the strategic positions of the Tps either among new-formed blood vessels (Fig. 9), or surrounding them (Fig. 10). The new-formed blood vessels have typical tall endothelial cells with numerous organelles and a narrow and anfractuous lumen (Figs 11 and 12). The endothelium has many transcytosis vesicles.

Bottom Line: Higher resolution images provided the following information: (a) the intercellular space between the abluminal face of endothelium and its surrounding TCs is frequently less than 50 nm; (b) TCs establish multiple direct nanocontacts with endothelial cells, where the extracellular space seems obliterated; such nanocontacts have a length of 0.4-1.5 μm; (c) the absence of basal membrane on the abluminal face of endothelial cell.Besides the physical contacts (either nanoscopic or microscopic) TCs presumably contribute to neo-angiognesis via paracrine secretion (as shown by immunocytochemistry for VEGF or NOS2).Last but not least, TCs contain measurable quantities of angiogenic microRNAs (e.g. let-7e, 10a, 21, 27b, 100, 126-3p, 130a, 143, 155, 503).

View Article: PubMed Central - PubMed

Affiliation: Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Show MeSH
Related in: MedlinePlus