Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis.
Bottom Line: Higher resolution images provided the following information: (a) the intercellular space between the abluminal face of endothelium and its surrounding TCs is frequently less than 50 nm; (b) TCs establish multiple direct nanocontacts with endothelial cells, where the extracellular space seems obliterated; such nanocontacts have a length of 0.4-1.5 μm; (c) the absence of basal membrane on the abluminal face of endothelial cell.Besides the physical contacts (either nanoscopic or microscopic) TCs presumably contribute to neo-angiognesis via paracrine secretion (as shown by immunocytochemistry for VEGF or NOS2).Last but not least, TCs contain measurable quantities of angiogenic microRNAs (e.g. let-7e, 10a, 21, 27b, 100, 126-3p, 130a, 143, 155, 503).
Affiliation: Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.Show MeSH
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Mentions: For underlining the involvement of TC in angiogenesis, Figures 9 and 10 show the strategic positions of the Tps either among new-formed blood vessels (Fig. 9), or surrounding them (Fig. 10). The new-formed blood vessels have typical tall endothelial cells with numerous organelles and a narrow and anfractuous lumen (Figs 11 and 12). The endothelium has many transcytosis vesicles.
Affiliation: Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.