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Regulatory T cell: a protection for tumour cells.

Wang Y, Ma Y, Fang Y, Wu S, Liu L, Fu D, Shen X - J. Cell. Mol. Med. (2012)

Bottom Line: Characterized by immunosuppression regulatory T cells (Tregs) play a key role in maintaining immune tolerance.A growing number of tumours have been found with Tregs accumulating in microenvironment and patients with high density of Tregs in tumour stroma get a worse prognosis, which suggests that Tregs may inhibit anti-tumour immunity in stroma, resulting in a poor prognosis.In this paper, we demonstrate the accumulation of Tregs in tumour stroma and the possible suppressive mechanisms.

View Article: PubMed Central - PubMed

Affiliation: The Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai, China.

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The target cells of regulatory T cells. By secreting inhibitory cytokines and expressing suppressive receptor, regulatory T cells not only keep homeostasis in vivo, but also inhibit immune surveillance in tumour microenvironment. Regulatory T cells nearly suppress all of lymphocytes, including T cells, B cells, NKs, DCs, and macrophage (Mac). Because of the suppression, anti-tumour immunity is significantly weakened.
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fig03: The target cells of regulatory T cells. By secreting inhibitory cytokines and expressing suppressive receptor, regulatory T cells not only keep homeostasis in vivo, but also inhibit immune surveillance in tumour microenvironment. Regulatory T cells nearly suppress all of lymphocytes, including T cells, B cells, NKs, DCs, and macrophage (Mac). Because of the suppression, anti-tumour immunity is significantly weakened.

Mentions: The major roles Tregs plays in in vivo are keeping homeostasis and inhibiting severe immune responses. Most of immune cells in the tumour stroma, such as T lymphocytes, B lymphocytes, NK, DCs, macrophage, are targets of Tregs [66-71]. Redundant Tregs accumulating in a tumour not only keep homeostasis, but also restrain local anti-tumour immunity (Fig. 3). Because of the suppression, tumour cells evade from body immune surveillance, hence a poor prognosis.


Regulatory T cell: a protection for tumour cells.

Wang Y, Ma Y, Fang Y, Wu S, Liu L, Fu D, Shen X - J. Cell. Mol. Med. (2012)

The target cells of regulatory T cells. By secreting inhibitory cytokines and expressing suppressive receptor, regulatory T cells not only keep homeostasis in vivo, but also inhibit immune surveillance in tumour microenvironment. Regulatory T cells nearly suppress all of lymphocytes, including T cells, B cells, NKs, DCs, and macrophage (Mac). Because of the suppression, anti-tumour immunity is significantly weakened.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3822920&req=5

fig03: The target cells of regulatory T cells. By secreting inhibitory cytokines and expressing suppressive receptor, regulatory T cells not only keep homeostasis in vivo, but also inhibit immune surveillance in tumour microenvironment. Regulatory T cells nearly suppress all of lymphocytes, including T cells, B cells, NKs, DCs, and macrophage (Mac). Because of the suppression, anti-tumour immunity is significantly weakened.
Mentions: The major roles Tregs plays in in vivo are keeping homeostasis and inhibiting severe immune responses. Most of immune cells in the tumour stroma, such as T lymphocytes, B lymphocytes, NK, DCs, macrophage, are targets of Tregs [66-71]. Redundant Tregs accumulating in a tumour not only keep homeostasis, but also restrain local anti-tumour immunity (Fig. 3). Because of the suppression, tumour cells evade from body immune surveillance, hence a poor prognosis.

Bottom Line: Characterized by immunosuppression regulatory T cells (Tregs) play a key role in maintaining immune tolerance.A growing number of tumours have been found with Tregs accumulating in microenvironment and patients with high density of Tregs in tumour stroma get a worse prognosis, which suggests that Tregs may inhibit anti-tumour immunity in stroma, resulting in a poor prognosis.In this paper, we demonstrate the accumulation of Tregs in tumour stroma and the possible suppressive mechanisms.

View Article: PubMed Central - PubMed

Affiliation: The Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai, China.

Show MeSH
Related in: MedlinePlus