Regulatory T cell: a protection for tumour cells.
Bottom Line: Characterized by immunosuppression regulatory T cells (Tregs) play a key role in maintaining immune tolerance.A growing number of tumours have been found with Tregs accumulating in microenvironment and patients with high density of Tregs in tumour stroma get a worse prognosis, which suggests that Tregs may inhibit anti-tumour immunity in stroma, resulting in a poor prognosis.In this paper, we demonstrate the accumulation of Tregs in tumour stroma and the possible suppressive mechanisms.
Affiliation: The Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai, China.Show MeSH
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Mentions: The major roles Tregs plays in in vivo are keeping homeostasis and inhibiting severe immune responses. Most of immune cells in the tumour stroma, such as T lymphocytes, B lymphocytes, NK, DCs, macrophage, are targets of Tregs [66-71]. Redundant Tregs accumulating in a tumour not only keep homeostasis, but also restrain local anti-tumour immunity (Fig. 3). Because of the suppression, tumour cells evade from body immune surveillance, hence a poor prognosis.
Affiliation: The Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai, China.