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Cardiac shock wave therapy: assessment of safety and new insights into mechanisms of tissue regeneration.

Di Meglio F, Nurzynska D, Castaldo C, Miraglia R, Romano V, De Angelis A, Piegari E, Russo S, Montagnani S - J. Cell. Mol. Med. (2012)

Bottom Line: ECSW application did not provoke arrhythmia or increase the troponin-I level.At all time points, the left ventricular ejection fraction and fractional shortening remained stable.In conclusion, non-invasive ECSW therapy is a safe and effective way of activating cardiac stem cells and myocardial regeneration.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy.

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ECSW application increases the number of cardiac primitive cells. Clusters of c-kit-positive, Ki67-positive and Flk-1-positive cells were observed in the myocardium of ECSW-treated animals only. Representative images of the serial sections of cardiac tissue stained by immunohistochemistry for c-kit (A), Flk-1 (B) and Ki67 (C) are shown. Scale bar: 50 μm.
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fig04: ECSW application increases the number of cardiac primitive cells. Clusters of c-kit-positive, Ki67-positive and Flk-1-positive cells were observed in the myocardium of ECSW-treated animals only. Representative images of the serial sections of cardiac tissue stained by immunohistochemistry for c-kit (A), Flk-1 (B) and Ki67 (C) are shown. Scale bar: 50 μm.

Mentions: C-kit (also known as CD117)-positive cardiac cells represent a population of cardiac stem cells and progenitors/precursors of cardiac cell lineages in the developing [19] and adult heart [20]. In contrast to control hearts, immunohistochemical analysis of the rat myocardium at 3 months after ECSW treatment revealed the presence of c-kit–positive cell clusters (Fig. 4A). ECSW treatment increased the number of c-kit–positive cells 2.65-fold compared to control hearts (279.1 ± 52.86 versus 105.4 ± 15.25 c-kit–positive cells/100 mm2; n = 4, P < 0.05).


Cardiac shock wave therapy: assessment of safety and new insights into mechanisms of tissue regeneration.

Di Meglio F, Nurzynska D, Castaldo C, Miraglia R, Romano V, De Angelis A, Piegari E, Russo S, Montagnani S - J. Cell. Mol. Med. (2012)

ECSW application increases the number of cardiac primitive cells. Clusters of c-kit-positive, Ki67-positive and Flk-1-positive cells were observed in the myocardium of ECSW-treated animals only. Representative images of the serial sections of cardiac tissue stained by immunohistochemistry for c-kit (A), Flk-1 (B) and Ki67 (C) are shown. Scale bar: 50 μm.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3822862&req=5

fig04: ECSW application increases the number of cardiac primitive cells. Clusters of c-kit-positive, Ki67-positive and Flk-1-positive cells were observed in the myocardium of ECSW-treated animals only. Representative images of the serial sections of cardiac tissue stained by immunohistochemistry for c-kit (A), Flk-1 (B) and Ki67 (C) are shown. Scale bar: 50 μm.
Mentions: C-kit (also known as CD117)-positive cardiac cells represent a population of cardiac stem cells and progenitors/precursors of cardiac cell lineages in the developing [19] and adult heart [20]. In contrast to control hearts, immunohistochemical analysis of the rat myocardium at 3 months after ECSW treatment revealed the presence of c-kit–positive cell clusters (Fig. 4A). ECSW treatment increased the number of c-kit–positive cells 2.65-fold compared to control hearts (279.1 ± 52.86 versus 105.4 ± 15.25 c-kit–positive cells/100 mm2; n = 4, P < 0.05).

Bottom Line: ECSW application did not provoke arrhythmia or increase the troponin-I level.At all time points, the left ventricular ejection fraction and fractional shortening remained stable.In conclusion, non-invasive ECSW therapy is a safe and effective way of activating cardiac stem cells and myocardial regeneration.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy.

Show MeSH
Related in: MedlinePlus