Cardiac shock wave therapy: assessment of safety and new insights into mechanisms of tissue regeneration.
Bottom Line: ECSW application did not provoke arrhythmia or increase the troponin-I level.At all time points, the left ventricular ejection fraction and fractional shortening remained stable.In conclusion, non-invasive ECSW therapy is a safe and effective way of activating cardiac stem cells and myocardial regeneration.
Affiliation: Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy.Show MeSH
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Mentions: C-kit (also known as CD117)-positive cardiac cells represent a population of cardiac stem cells and progenitors/precursors of cardiac cell lineages in the developing  and adult heart . In contrast to control hearts, immunohistochemical analysis of the rat myocardium at 3 months after ECSW treatment revealed the presence of c-kit–positive cell clusters (Fig. 4A). ECSW treatment increased the number of c-kit–positive cells 2.65-fold compared to control hearts (279.1 ± 52.86 versus 105.4 ± 15.25 c-kit–positive cells/100 mm2; n = 4, P < 0.05).
Affiliation: Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy.