Caveolin induces cardioprotection through epigenetic regulation.
Bottom Line: Cav-1 KO mouse also decreased the translocation of forkhead transcription factor (FOXO3a) to the nucleus and reduced the induction of the expression of SIRT-1 in the preconditioned heart.Cardioprotective property of Cav-1 was further confirmed by reduced ventricular function, increased cardiomyocyte apoptosis, increased expression of junas kinase (JNK) and Bax and decreased expression of phospho-adenosine monophosphate-activated protein kinase (AMPK), phospho-AKT and B cell lymphoma-2 (Bcl-2) in Cav-1 KO preconditioned heart.The results clearly indicate that Cav-1 induces cardioprotection through epigenetic regulation.
Affiliation: Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06-030-1110, USA.Show MeSH
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Mentions: Both HAT and HDAC activities were measured by calorimetric method using the nuclear fraction of the heart tissues. WT PC heart showed significantly high HAT activity compared to WT I/R, Cav-1 I/R and Cav-1 PC groups. Whereas WT PC heart showed significantly lower HDAC activity compared to the other groups (Fig. 4).
Affiliation: Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06-030-1110, USA.