K ATP channel agonists preserve connexin43 protein in infarcted rats by a protein kinase C-dependent pathway.
Bottom Line: Myocardial connexin43 level was significantly decreased in vehicle-treated infarcted rats compared with sham.The beneficial effects of K(ATP) channel agonists were blocked by either glibenclamide or 5-hydroxydecanoate.The specific PKC(ε) antagonist, myristoylated PKC(ε) V1-2 peptide, did not have additional beneficial effects on connexin43 phosphorylation compared with rats treated with nicorandil alone.
Affiliation: Department of Medicine, Cardiology Section, Taipei Medical University and Chi-Mei Medical Center, Tainan, Taiwan. firstname.lastname@example.orgShow MeSH
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Mentions: To further elucidate the physiological effect of enhanced Cx43 level, ventricular pacing was performed. The arrhythmia score in the sham-operated rats was very low (0.08 ± 0.29; Fig. 7). Either nicorandil or pinacidil significantly decreased the inducibility of ventricular tachyarrhythmias compared with the vehicle. The beneficial effects of nicorandil and pinacidil on arrhythmic score were abolished by administering glibenclamide.
Affiliation: Department of Medicine, Cardiology Section, Taipei Medical University and Chi-Mei Medical Center, Tainan, Taiwan. email@example.com