Regulation of the (pro)renin-renin receptor in cardiac remodelling.
Bottom Line: Most interestingly in DCM patients, a significant 8.7-fold (P < 0.05) increase was observed.Thus, protein expression paralleled gene expression.These results demonstrate that (P)RR expression is strongly up-regulated both in rodent models of heart failure and in the failing human heart, hinting to a potential role for (P)RR in cardiac pathophysiology.
Affiliation: University Medical Center Groningen, Thorax Center, Department of Cardiology, University of Groningen, The Netherlands.Show MeSH
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Mentions: Having established (P)RR expression in the heart, we next investigated (P)RR expression in other organs. At the mRNA level, maximal (P)RR expression was observed in brain, followed by kidney, intestine, liver and heart (Fig. 3A). In muscle and lung, expression was nearly absent. At the protein level, maximal expression was observed in kidney followed by liver, brain, heart and intestine (Fig. 3B and C). Again, expression was low in muscle and lung. Except for brain, mRNA and protein expression levels paralleled each other.
Affiliation: University Medical Center Groningen, Thorax Center, Department of Cardiology, University of Groningen, The Netherlands.