Platelet-derived growth factor receptor-β-positive telocytes in skeletal muscle interstitium.
Bottom Line: We found that in human skeletal muscle TCs were constantly located around intermediate and small blood vessels and endomysial capillaries.Laminin labelling showed that TCs are not enclosed or surrounded by a basal lamina in contrast to mural cells.In conclusion, a) PDGFR-β could be used as a marker for TCs and b) TCs are presumably a transitional population in the complex process of mural cell recruitment during angiogenesis and vascular remodelling.
Affiliation: Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.Show MeSH
Mentions: We show here, based on in situ double immunolabelling, the presence of c-kit-positive TCs in skeletal muscle, surrounding small blood vessels marked by the endothelial marker CD31 (Fig. 1A), or located in the vicinity of endomysial capillaries (Fig. 1A and B), results confirmed by electron microscopy (Fig. 1C). As shown previously, perivascular TCs synthesize VEGF (Fig. 2).
Affiliation: Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.