Luteolin suppresses UVB-induced photoageing by targeting JNK1 and p90 RSK2.
Bottom Line: Luteolin, a bioactive compound found in chilli, onion, broccoli, celery and carrot, has been reported to exhibit anti-photoageing effects in vitro.Luteolin was found to inhibit UVB-induced MMP-1 expression in HaCaT cells, as well as UVB-induced activation of AP-1, a well-known transcription factor targeting the MMP-1 promoter region, as well as c-Fos and c-Jun, which comprise the AP-1 complex.Taken together, our observations suggest that luteolin exhibits anti-photoageing effects in vitro and in vivo and may have potential as a treatment for the prevention of skin ageing.
Affiliation: WCU Biomodulation Major, Center for Food and Bioconvergence, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.Show MeSH
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Mentions: UVB is known to induce Activator Protein-1 (AP-1) and MMP-1 is a target gene with an AP-1 binding site in its promoter region 33, 34. The pretreatment of cells with luteolin inhibited UVB-induced AP-1 transactivation in HaCaT cells stably transfected with an AP-1 luciferase plasmid (Fig. 2A). We next investigated the effect of luteolin on UVB-induced c-Fos promoter activation. Pretreatment of cells with luteolin reduced UVB-induced c-Fos gene expression in HaCaT cells that were stably transfected with c-Fos luciferase plasmid (Fig. 2B).
Affiliation: WCU Biomodulation Major, Center for Food and Bioconvergence, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.