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Changes of lysosomes in the earliest stages of the development of atherosclerosis.

Bobryshev YV, Shchelkunova TA, Morozov IA, Rubtsov PM, Sobenin IA, Orekhov AN, Smirnov AN - J. Cell. Mol. Med. (2013)

Bottom Line: One of hypotheses of atherosclerosis is based on a presumption that the zones prone to the development of atherosclerosis contain lysosomes which are characterized by enzyme deficiency and thus, are unable to dispose of lipoproteins.There were no significant changes found in the key mRNAs encoding for the components of endosome/lysosome compartment in initial atherosclerotic lesions, but in fatty streaks, the contents of EEA1 and Rab5a mRNAs were found to be diminished while the contents of CD68 and p62 mRNAs were increased, compared with the intact tissue.The study reinforces a view that changes occurring in lysosomes play a role in atherogenesis from the very earlier stages of the disease.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine, School of Medical Sciences, University of New South Wales, Kensington, NSW, Australia. y.bobryshev@unsw.edu.au

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The ratios of the contents of mRNAs encoding for the components of endosome/lysosome compartment in pairs of atherosclerotically injured/intact human aorta. Black bars: initial lesion/intact tissue ratios; hatched bars: fatty streak/intact tissue ratios. Symbol # shows significant difference from 1.0.
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fig05: The ratios of the contents of mRNAs encoding for the components of endosome/lysosome compartment in pairs of atherosclerotically injured/intact human aorta. Black bars: initial lesion/intact tissue ratios; hatched bars: fatty streak/intact tissue ratios. Symbol # shows significant difference from 1.0.

Mentions: As seen from Figure 5, no significant changes in mRNAs that encode the components of endosome/lysosome compartment were found in the initial lesion (Type I lesion) of the aorta. However, in fatty streaks (Type II lesion), the contents of EEA1 and Rab5a mRNAs diminished while the contents of p62 and CD68 mRNAs were increased compared with the intact tissue. Prominent changes were observed in coupling between the contents of mRNAs encoding for molecules that govern the functioning of endosomes and lysosomes in both Type I and Type II lesions. Although the total amounts of correlations were comparable in the intact and atherosclerotically injured areas tissues (7, 9 and 6 in intact tissue, initial lesion and fatty streak respectively), the distribution of correlations between mRNAs varied in the different types of atherosclerotic lesions.


Changes of lysosomes in the earliest stages of the development of atherosclerosis.

Bobryshev YV, Shchelkunova TA, Morozov IA, Rubtsov PM, Sobenin IA, Orekhov AN, Smirnov AN - J. Cell. Mol. Med. (2013)

The ratios of the contents of mRNAs encoding for the components of endosome/lysosome compartment in pairs of atherosclerotically injured/intact human aorta. Black bars: initial lesion/intact tissue ratios; hatched bars: fatty streak/intact tissue ratios. Symbol # shows significant difference from 1.0.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3822815&req=5

fig05: The ratios of the contents of mRNAs encoding for the components of endosome/lysosome compartment in pairs of atherosclerotically injured/intact human aorta. Black bars: initial lesion/intact tissue ratios; hatched bars: fatty streak/intact tissue ratios. Symbol # shows significant difference from 1.0.
Mentions: As seen from Figure 5, no significant changes in mRNAs that encode the components of endosome/lysosome compartment were found in the initial lesion (Type I lesion) of the aorta. However, in fatty streaks (Type II lesion), the contents of EEA1 and Rab5a mRNAs diminished while the contents of p62 and CD68 mRNAs were increased compared with the intact tissue. Prominent changes were observed in coupling between the contents of mRNAs encoding for molecules that govern the functioning of endosomes and lysosomes in both Type I and Type II lesions. Although the total amounts of correlations were comparable in the intact and atherosclerotically injured areas tissues (7, 9 and 6 in intact tissue, initial lesion and fatty streak respectively), the distribution of correlations between mRNAs varied in the different types of atherosclerotic lesions.

Bottom Line: One of hypotheses of atherosclerosis is based on a presumption that the zones prone to the development of atherosclerosis contain lysosomes which are characterized by enzyme deficiency and thus, are unable to dispose of lipoproteins.There were no significant changes found in the key mRNAs encoding for the components of endosome/lysosome compartment in initial atherosclerotic lesions, but in fatty streaks, the contents of EEA1 and Rab5a mRNAs were found to be diminished while the contents of CD68 and p62 mRNAs were increased, compared with the intact tissue.The study reinforces a view that changes occurring in lysosomes play a role in atherogenesis from the very earlier stages of the disease.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine, School of Medical Sciences, University of New South Wales, Kensington, NSW, Australia. y.bobryshev@unsw.edu.au

Show MeSH
Related in: MedlinePlus