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Overexpression of Sema3a in myocardial infarction border zone decreases vulnerability of ventricular tachycardia post-myocardial infarction in rats.

Chen RH, Li YG, Jiao KL, Zhang PP, Sun Y, Zhang LP, Fong XF, Li W, Yu Y - J. Cell. Mol. Med. (2013)

Bottom Line: Inducibility of VT by PES was significantly lower in the SLV group [30.8% (4/13)] than in PBS [66.7% (8/12)] and MLV [61.5% (8/13)] groups (P < 0.05). mRNA and protein expressions of Sema3a were significantly higher and the protein expression of GAP43 and TH was significantly lower at 7 days after transduction in SLV group compared with PBS, MLV and CON groups.Myocardial EPI in the border zone was also significantly lower in SLV group than in PBS and MLV group (8.73 ± 1.30 vs. 11.94 ± 1.71 and 12.24 ± 1.54 μg/g protein, P < 0.001).Overexpression of Sema3a in MI border zone could reduce the inducibility of ventricular arrhythmias by reducing sympathetic hyper-reinnervation after infarction.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, School of Medicine, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, China.

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Incidence of VT and arrhythmia score at 1 week after infarction and microinjection. (A) Incidence of non–self-terminating VTs during PES. (B) Arrhythmia score in the SLV group was significantly lower than that in MLV and PBS groups at 1 week after infarction and microinjecttion. *P = 0.018, versus the PBS group and †P = 0.025, versus the MLV group respectively.
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fig03: Incidence of VT and arrhythmia score at 1 week after infarction and microinjection. (A) Incidence of non–self-terminating VTs during PES. (B) Arrhythmia score in the SLV group was significantly lower than that in MLV and PBS groups at 1 week after infarction and microinjecttion. *P = 0.018, versus the PBS group and †P = 0.025, versus the MLV group respectively.

Mentions: The ECG measurements before electrophysiological test of all rats were summarized in Table 3. The QTc interval was significantly shortened in the SLV group compared with the PBS and MLV groups at 1-week post-LAD and microinjection. The incidence of VT by S1S1 stimulus at room temperature during PES was significantly lower in SLV group than in PBS and MLV groups (Fig. 3a). Arrhythmia score was also significantly lower in SLV group than in PBS and MLV groups (Fig. 3b). QTc interval, inducibility of VT and arrhythmias score are significantly higher in PBS and MLV groups than in control group and these parameters are similar between control group and SLV group.


Overexpression of Sema3a in myocardial infarction border zone decreases vulnerability of ventricular tachycardia post-myocardial infarction in rats.

Chen RH, Li YG, Jiao KL, Zhang PP, Sun Y, Zhang LP, Fong XF, Li W, Yu Y - J. Cell. Mol. Med. (2013)

Incidence of VT and arrhythmia score at 1 week after infarction and microinjection. (A) Incidence of non–self-terminating VTs during PES. (B) Arrhythmia score in the SLV group was significantly lower than that in MLV and PBS groups at 1 week after infarction and microinjecttion. *P = 0.018, versus the PBS group and †P = 0.025, versus the MLV group respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3822813&req=5

fig03: Incidence of VT and arrhythmia score at 1 week after infarction and microinjection. (A) Incidence of non–self-terminating VTs during PES. (B) Arrhythmia score in the SLV group was significantly lower than that in MLV and PBS groups at 1 week after infarction and microinjecttion. *P = 0.018, versus the PBS group and †P = 0.025, versus the MLV group respectively.
Mentions: The ECG measurements before electrophysiological test of all rats were summarized in Table 3. The QTc interval was significantly shortened in the SLV group compared with the PBS and MLV groups at 1-week post-LAD and microinjection. The incidence of VT by S1S1 stimulus at room temperature during PES was significantly lower in SLV group than in PBS and MLV groups (Fig. 3a). Arrhythmia score was also significantly lower in SLV group than in PBS and MLV groups (Fig. 3b). QTc interval, inducibility of VT and arrhythmias score are significantly higher in PBS and MLV groups than in control group and these parameters are similar between control group and SLV group.

Bottom Line: Inducibility of VT by PES was significantly lower in the SLV group [30.8% (4/13)] than in PBS [66.7% (8/12)] and MLV [61.5% (8/13)] groups (P < 0.05). mRNA and protein expressions of Sema3a were significantly higher and the protein expression of GAP43 and TH was significantly lower at 7 days after transduction in SLV group compared with PBS, MLV and CON groups.Myocardial EPI in the border zone was also significantly lower in SLV group than in PBS and MLV group (8.73 ± 1.30 vs. 11.94 ± 1.71 and 12.24 ± 1.54 μg/g protein, P < 0.001).Overexpression of Sema3a in MI border zone could reduce the inducibility of ventricular arrhythmias by reducing sympathetic hyper-reinnervation after infarction.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, School of Medicine, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, China.

Show MeSH
Related in: MedlinePlus