Low-dose taxotere enhances the ability of sorafenib to induce apoptosis in gastric cancer models.
Bottom Line: Apoptosis induction was associated with caspase-3 and -9 activation and mitochondrial membrane depolarization.This synergism was probably due to the induction of an anomalous multidiploid G0-G1 peak and to consequent mitotic catastrophe, which increased sensitivity to sorafenib.Consistent with in vitro results, the docetaxel-sorafenib sequence exhibited high therapeutic efficacy in NCI-N87 mouse xenografts producing tumour weight inhibition (> 65%), tumour growth delay (up to 25 days) and increased mouse survival (30%).
Affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: Cell lines were characterized by different molecular profiles. All cell lines expressed c-raf, b-raf and PDGF receptor β. VEGF receptor expression was found in AKG, KKP and NCI-N87 cells, while the expression of EGF receptor was only present in the last two. k-ras mutation analysis revealed gene alterations in GK2, KKP and NCI-N87 cells (Fig. 1A).
Affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy. firstname.lastname@example.org