Ovarian cancer cytoreduction induces changes in T cell population subsets reducing immunosuppression.
Bottom Line: Primary cytoreduction is able to increase circulating CD4 and CD8 effector cells and decrease CD4 naïve T cells.In conclusion, we demonstrate in ovarian cancer that primary debulking is associated with a reduction of circulating T(reg) and an increase in CD8 T-cell function.Debulking plays a beneficial systemic effect by reverting immunosuppression and restoring immunological fitness.
Affiliation: Department of Experimental Medicine, 'Sapienza' University of Rome, Italy.Show MeSH
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Mentions: CD4 and CD8 T-cell populations were analysed by cytofluorimetry for the expression of CD45RA and CCR7 markers to evaluate the proportion of naïve (CD45RA+CCR7+), central memory (CD45RA−CCR7+), effector memory (CD45RA−CCR7−) and terminally differentiated effector (CD45RA+CCR7−) subsets  (Fig. 3). Figure 3A shows the changes of circulating CD4 T cell after tumour removal. Before surgery, the relative proportion of CD4 effector T cells was significantly higher (P < 0.05) in pOC patients when compared with the control group. There was a significant increase in CD4 effector T cells after surgery (P < 0.05). Before surgery, CD4 naïve T cells were significantly lower in the pOC group as compared to controls. In the pOC group, there was a significant decrease in CD4 naïve T cells after surgery (P < 0.01).
Affiliation: Department of Experimental Medicine, 'Sapienza' University of Rome, Italy.