Human umbilical cord mesenchymal stem cells suppress breast cancer tumourigenesis through direct cell-cell contact and internalization.
Bottom Line: Also, treatment with HUMSC injection was efficacious in both in situ and metastatic breast cancers in the animal models.Since HUMSCs were proved to efficaciously suppress breast cancer tumourigenesis both in vitro and in vivo, it is our expectation that treatment with HUMSCs can be a viable therapy for breast cancer in the near future.In addition, we share a new point of view on the role of HUMSCs in foetal development during pregnancy.
Affiliation: Genomics Research Center, Academia Sinica, Taipei, Taiwan.Show MeSH
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Mentions: The cell-in-cell structure of selected HUMSC internalized within MDA MB-23l was manifested on confocal microscopy (Fig. 1D), with substance from HUMSC intermixed within MDA-MB231 noted (Fig. 2A). Although less dominant, it was also found that in a few cases, some substance from MDA-MB231 had been intermixed within HUMSC (Fig. S2A), implying that infusion of substance from MDA-MB231 into HUMSC also occurred during their interaction.
Affiliation: Genomics Research Center, Academia Sinica, Taipei, Taiwan.