Human umbilical cord mesenchymal stem cells suppress breast cancer tumourigenesis through direct cell-cell contact and internalization.
Bottom Line: Also, treatment with HUMSC injection was efficacious in both in situ and metastatic breast cancers in the animal models.Since HUMSCs were proved to efficaciously suppress breast cancer tumourigenesis both in vitro and in vivo, it is our expectation that treatment with HUMSCs can be a viable therapy for breast cancer in the near future.In addition, we share a new point of view on the role of HUMSCs in foetal development during pregnancy.
Affiliation: Genomics Research Center, Academia Sinica, Taipei, Taiwan.Show MeSH
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Mentions: As a first step, we used Cellomics ArrayScan to observe how MDA-MB231 responds to HUMSC. In most of the co-cultured wells, the number of MDA-MB231 decreased slightly, whereas in some wells, the number of MDA-MB231 decreased dramatically. The frequency of the more ‘active’ HUMSCs versus the total number of sample tested was 1/6 (16.67%) (Fig. 1A). The HUMSCs were found to have the ability to suppress MDA-MB231 cell growth to different degrees, so the somehow more ‘active’ HUMSCs with better ability to suppress tumourigenesis were selected for further experiments.
Affiliation: Genomics Research Center, Academia Sinica, Taipei, Taiwan.