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Erythropoietin attenuates the sequels of ischaemic spinal cord injury with enhanced recruitment of CD34+ cells in mice.

Hirano K, Wagner K, Mark P, Pittermann E, Gäbel R, Furlani D, Li W, Vollmar B, Yamada T, Steinhoff G, Ma N - J. Cell. Mol. Med. (2012)

Bottom Line: Immunohistochemistry was used to detect CD34(+) cells and the expression of brain-derived neurotrophic factor and vascular endothelial growth factor.Erythropoietin demonstrated neuroprotective effects in the ischaemic spinal cord, improving neurological function and attenuating motor neuron loss.These effects may have been mediated by recruited CD34(+) cells, and enhanced expression of brain-derived neurotrophic factor and vascular endothelial growth factor.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiac Surgery, University of Rostock, Rostock, Germany.

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Related in: MedlinePlus

Survival rates of groups subjected to 7-min. ischaemia (A) and 9-min. ischaemia (B) are illustrated using Kaplan–Meier survival curves. 7C: control group subjected to 7-min. ischaemia; 7E: EPO group subjected to 7-min. ischaemia; 9C: control group subjected to 9-min. ischaemia; 9E: EPO group subjected to 9-min. ischaemia. Survival rates at day 2 after SCI were 70.6%, 68.8%, 73.3% and 74.3%, and 65.5%, 63.0%, 62.9% and 63.7% at day 7 in the 7C, 7E, 9C and 9E groups, respectively. There were no significant differences in survival rate between groups 7C and 7E (P= 0.797) or between groups 9C and 9E (P= 0.971), according to the Log-rank test.
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fig02: Survival rates of groups subjected to 7-min. ischaemia (A) and 9-min. ischaemia (B) are illustrated using Kaplan–Meier survival curves. 7C: control group subjected to 7-min. ischaemia; 7E: EPO group subjected to 7-min. ischaemia; 9C: control group subjected to 9-min. ischaemia; 9E: EPO group subjected to 9-min. ischaemia. Survival rates at day 2 after SCI were 70.6%, 68.8%, 73.3% and 74.3%, and 65.5%, 63.0%, 62.9% and 63.7% at day 7 in the 7C, 7E, 9C and 9E groups, respectively. There were no significant differences in survival rate between groups 7C and 7E (P= 0.797) or between groups 9C and 9E (P= 0.971), according to the Log-rank test.

Mentions: Survival rates at day 2 after SCI were 70.6%, 68.8%, 73.3% and 74.3%, and those at day 7 were 65.5%, 63.0%, 62.9% and 63.7% in the 7C, 7E, 9C and 9E groups, respectively. There was no significant difference in the survival rate between the 7C and 7E groups (P= 0.797) or between the 9C and 9E groups (P= 0.971) (Fig. 2). At necropsy, bowel necrosis was detected in three mice from group 7C, three from 9C and one from 9E, indicating that there was no evidence that EPO exacerbated thromboembolism.


Erythropoietin attenuates the sequels of ischaemic spinal cord injury with enhanced recruitment of CD34+ cells in mice.

Hirano K, Wagner K, Mark P, Pittermann E, Gäbel R, Furlani D, Li W, Vollmar B, Yamada T, Steinhoff G, Ma N - J. Cell. Mol. Med. (2012)

Survival rates of groups subjected to 7-min. ischaemia (A) and 9-min. ischaemia (B) are illustrated using Kaplan–Meier survival curves. 7C: control group subjected to 7-min. ischaemia; 7E: EPO group subjected to 7-min. ischaemia; 9C: control group subjected to 9-min. ischaemia; 9E: EPO group subjected to 9-min. ischaemia. Survival rates at day 2 after SCI were 70.6%, 68.8%, 73.3% and 74.3%, and 65.5%, 63.0%, 62.9% and 63.7% at day 7 in the 7C, 7E, 9C and 9E groups, respectively. There were no significant differences in survival rate between groups 7C and 7E (P= 0.797) or between groups 9C and 9E (P= 0.971), according to the Log-rank test.
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Related In: Results  -  Collection

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fig02: Survival rates of groups subjected to 7-min. ischaemia (A) and 9-min. ischaemia (B) are illustrated using Kaplan–Meier survival curves. 7C: control group subjected to 7-min. ischaemia; 7E: EPO group subjected to 7-min. ischaemia; 9C: control group subjected to 9-min. ischaemia; 9E: EPO group subjected to 9-min. ischaemia. Survival rates at day 2 after SCI were 70.6%, 68.8%, 73.3% and 74.3%, and 65.5%, 63.0%, 62.9% and 63.7% at day 7 in the 7C, 7E, 9C and 9E groups, respectively. There were no significant differences in survival rate between groups 7C and 7E (P= 0.797) or between groups 9C and 9E (P= 0.971), according to the Log-rank test.
Mentions: Survival rates at day 2 after SCI were 70.6%, 68.8%, 73.3% and 74.3%, and those at day 7 were 65.5%, 63.0%, 62.9% and 63.7% in the 7C, 7E, 9C and 9E groups, respectively. There was no significant difference in the survival rate between the 7C and 7E groups (P= 0.797) or between the 9C and 9E groups (P= 0.971) (Fig. 2). At necropsy, bowel necrosis was detected in three mice from group 7C, three from 9C and one from 9E, indicating that there was no evidence that EPO exacerbated thromboembolism.

Bottom Line: Immunohistochemistry was used to detect CD34(+) cells and the expression of brain-derived neurotrophic factor and vascular endothelial growth factor.Erythropoietin demonstrated neuroprotective effects in the ischaemic spinal cord, improving neurological function and attenuating motor neuron loss.These effects may have been mediated by recruited CD34(+) cells, and enhanced expression of brain-derived neurotrophic factor and vascular endothelial growth factor.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiac Surgery, University of Rostock, Rostock, Germany.

Show MeSH
Related in: MedlinePlus