Restored perfusion and reduced inflammation in the infarcted heart after grafting stem cells with a hyaluronan-based scaffold.
Bottom Line: Apart from the inflammatory response, the native tissue positively interacted with the HYAFF(®) 11/MSCs construct modifying the extracellular matrix with a reduced presence of collagene and increased amount of proteoglycans.The border-zone cardiomyocytes also reacted favourably to the graft as a lower degree of cellular damage was found.These beneficial effects are superior to those obtained after grafting only the scaffold or MSCs, suggesting that a synergic action was achieved using the cell-integrated polymer construct.
Affiliation: Department of Biochemistry, University of Bologna, Bologna 40126, Italy. email@example.comShow MeSH
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Mentions: Blood vessels were identified in the infarct region as circular/oval structures lined by one or more vWF+ cells (Fig. 6a). The number of medium-sized vessels was significantly increased in the HYAFF®11 group relative to the MSCs group (P < 0.05; Fig. 6b). The number of capillaries and total vessels (capillaries + medium-sized vessels) was apparently increased in both groups treated with HYAFF-11, but this number did not reach statistical significance with respect to the untreated infarct group.
Affiliation: Department of Biochemistry, University of Bologna, Bologna 40126, Italy. firstname.lastname@example.org