Evidence for progressive reduction and loss of telocytes in the dermal cellular network of systemic sclerosis.
Bottom Line: We presently investigated telocyte distribution and features in the skin of SSc patients compared with normal skin.Telocyte damage and loss evolved differently according to SSc subsets and stages, being more rapid and severe in diffuse SSc.Briefly, in human skin telocytes are a distinct stromal cell population.
Affiliation: Department of Anatomy, Histology and Forensic Medicine, University of Florence, I-50134 Florence, Italy. email@example.comShow MeSH
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Mentions: Telocytes were severely reduced in the dermis of SSc patients, and most of them exhibited ultrastructural abnormalities (Figs 7 and 8). However, a few normal telocytes were also present in the majority of SSc patients (Figs 7 and 8). Fibroblasts, myofibroblasts, mast cells and macrophages were present, but only a few fibroblasts showed ultrastructural changes, in particular in advanced dcSSc patients.
Affiliation: Department of Anatomy, Histology and Forensic Medicine, University of Florence, I-50134 Florence, Italy. firstname.lastname@example.org