Evidence for progressive reduction and loss of telocytes in the dermal cellular network of systemic sclerosis.
Bottom Line: We presently investigated telocyte distribution and features in the skin of SSc patients compared with normal skin.Telocyte damage and loss evolved differently according to SSc subsets and stages, being more rapid and severe in diffuse SSc.Briefly, in human skin telocytes are a distinct stromal cell population.
Affiliation: Department of Anatomy, Histology and Forensic Medicine, University of Florence, I-50134 Florence, Italy. firstname.lastname@example.orgShow MeSH
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Mentions: Telocytes and endothelial cells were CD34-positive, and mast cells were c-kit-positive also in skin biopsies from patients with SSc (Figs 3 and 4). However, a striking reduction in telocytes was found in clinically affected skin of SSc patients, with relevant differences according to disease subsets and stages (Figs 3 and 4).
Affiliation: Department of Anatomy, Histology and Forensic Medicine, University of Florence, I-50134 Florence, Italy. email@example.com