Peritoneal repairing cells: a type of bone marrow derived progenitor cells involved in mesothelial regeneration.
Bottom Line: This was observed in the injured area as well as in the surrounding not-injured peritoneal surfaces.We suggest that PRC constitute a type of monocyte-derived cells, closely related with the tissue-repairing cells known as 'fibrocytes' and specifically involved in peritoneal reparation.Thus, our results constitute a synthesis of the different scenarios hitherto proposed about peritoneal regeneration, particularly recruitment of circulating progenitor cells and adhesion of free-floating coelomic cells.
Affiliation: Department of Animal Biology, Faculty of Science, University of Málaga, Málaga, Spain.Show MeSH
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Mentions: The injured peritoneal wall, after 48 hrs, showed extensive signs of reparation, with cells adhered to the denudated surface and displaying a variable degree of flattening (arrows in Fig. 4B). Surprisingly the contralateral peritoneal surface (Fig. 4C and D) showed a clear difference as compared with the control (unoperated) mice (Fig. 4A) because of the presence of rounded cells, loosely attached to the peritoneal surface. These features were never observed in control unoperated mice.
Affiliation: Department of Animal Biology, Faculty of Science, University of Málaga, Málaga, Spain.