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Mechanisms of the protective effects of BMSCs promoted by TMDR with heparinized bFGF-incorporated stent in pig model of acute myocardial ischemia.

Zhang GW, Liu XC, Li-Ling J, Luan Y, Ying YN, Wu XS, Zhao CH, Liu TJ, Lü F - J. Cell. Mol. Med. (2010)

Bottom Line: Autologous BMSCs were transplanted into the ischemic region in C group or around the channels in TSC group.Expression of von Willebrand factor, vascular endothelial growth factor, interleukin-1β, transforming growth factor-β(3) , cell proliferation and apoptosis, histological and morphological analyses, myocardial remodelling and cardiac function were evaluated at different time-points.Six weeks after the operation, the above indices were significantly improved in TSC group compared with others (P < 0.05), though C and TS groups also showed better results than the control group (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Tianjin Medical University Cardiovascular Clinical College & TEDA International Cardiovascular Hospital, Tianjin, China.

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The effects of combined treatment on cell proliferation. (A–D) show representative Ki-67-staining pictures in control, C, TS and TSC groups (DAB, ×400). (E) Quantization of Ki-67 stained cells in all groups. *P < 0.001 versus control group. ♦P < 0.001 versus C group. ▾P < 0.001 versus TS group. DAB: diaminobezidin staining.
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fig02: The effects of combined treatment on cell proliferation. (A–D) show representative Ki-67-staining pictures in control, C, TS and TSC groups (DAB, ×400). (E) Quantization of Ki-67 stained cells in all groups. *P < 0.001 versus control group. ♦P < 0.001 versus C group. ▾P < 0.001 versus TS group. DAB: diaminobezidin staining.

Mentions: Representative photographs of Ki-67 stained sections of different groups are shown in Figure 2A to D. The count of Ki-67+ cells revealed that cell proliferation has significantly increased in C group (15 ± 2 cell/hpf) and TS group (23 ± 2 cell/hpf) compared with the control group (9 ± 1 cell/hpf, P < 0.001), which was more significant in TSC group (40 ± 2 cell/hpf, P < 0.001) even at comparison with C and TS groups (Fig. 2E).


Mechanisms of the protective effects of BMSCs promoted by TMDR with heparinized bFGF-incorporated stent in pig model of acute myocardial ischemia.

Zhang GW, Liu XC, Li-Ling J, Luan Y, Ying YN, Wu XS, Zhao CH, Liu TJ, Lü F - J. Cell. Mol. Med. (2010)

The effects of combined treatment on cell proliferation. (A–D) show representative Ki-67-staining pictures in control, C, TS and TSC groups (DAB, ×400). (E) Quantization of Ki-67 stained cells in all groups. *P < 0.001 versus control group. ♦P < 0.001 versus C group. ▾P < 0.001 versus TS group. DAB: diaminobezidin staining.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3822621&req=5

fig02: The effects of combined treatment on cell proliferation. (A–D) show representative Ki-67-staining pictures in control, C, TS and TSC groups (DAB, ×400). (E) Quantization of Ki-67 stained cells in all groups. *P < 0.001 versus control group. ♦P < 0.001 versus C group. ▾P < 0.001 versus TS group. DAB: diaminobezidin staining.
Mentions: Representative photographs of Ki-67 stained sections of different groups are shown in Figure 2A to D. The count of Ki-67+ cells revealed that cell proliferation has significantly increased in C group (15 ± 2 cell/hpf) and TS group (23 ± 2 cell/hpf) compared with the control group (9 ± 1 cell/hpf, P < 0.001), which was more significant in TSC group (40 ± 2 cell/hpf, P < 0.001) even at comparison with C and TS groups (Fig. 2E).

Bottom Line: Autologous BMSCs were transplanted into the ischemic region in C group or around the channels in TSC group.Expression of von Willebrand factor, vascular endothelial growth factor, interleukin-1β, transforming growth factor-β(3) , cell proliferation and apoptosis, histological and morphological analyses, myocardial remodelling and cardiac function were evaluated at different time-points.Six weeks after the operation, the above indices were significantly improved in TSC group compared with others (P < 0.05), though C and TS groups also showed better results than the control group (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Tianjin Medical University Cardiovascular Clinical College & TEDA International Cardiovascular Hospital, Tianjin, China.

Show MeSH
Related in: MedlinePlus