Mechanisms of the protective effects of BMSCs promoted by TMDR with heparinized bFGF-incorporated stent in pig model of acute myocardial ischemia.
Bottom Line: Autologous BMSCs were transplanted into the ischemic region in C group or around the channels in TSC group.Expression of von Willebrand factor, vascular endothelial growth factor, interleukin-1β, transforming growth factor-β(3) , cell proliferation and apoptosis, histological and morphological analyses, myocardial remodelling and cardiac function were evaluated at different time-points.Six weeks after the operation, the above indices were significantly improved in TSC group compared with others (P < 0.05), though C and TS groups also showed better results than the control group (P < 0.05).
Affiliation: Department of Surgery, Tianjin Medical University Cardiovascular Clinical College & TEDA International Cardiovascular Hospital, Tianjin, China.Show MeSH
Related in: MedlinePlus
Mentions: Representative photographs of Ki-67 stained sections of different groups are shown in Figure 2A to D. The count of Ki-67+ cells revealed that cell proliferation has significantly increased in C group (15 ± 2 cell/hpf) and TS group (23 ± 2 cell/hpf) compared with the control group (9 ± 1 cell/hpf, P < 0.001), which was more significant in TSC group (40 ± 2 cell/hpf, P < 0.001) even at comparison with C and TS groups (Fig. 2E).
Affiliation: Department of Surgery, Tianjin Medical University Cardiovascular Clinical College & TEDA International Cardiovascular Hospital, Tianjin, China.