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Mechanisms of the protective effects of BMSCs promoted by TMDR with heparinized bFGF-incorporated stent in pig model of acute myocardial ischemia.

Zhang GW, Liu XC, Li-Ling J, Luan Y, Ying YN, Wu XS, Zhao CH, Liu TJ, Lü F - J. Cell. Mol. Med. (2010)

Bottom Line: Autologous BMSCs were transplanted into the ischemic region in C group or around the channels in TSC group.Expression of von Willebrand factor, vascular endothelial growth factor, interleukin-1β, transforming growth factor-β(3) , cell proliferation and apoptosis, histological and morphological analyses, myocardial remodelling and cardiac function were evaluated at different time-points.Six weeks after the operation, the above indices were significantly improved in TSC group compared with others (P < 0.05), though C and TS groups also showed better results than the control group (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Tianjin Medical University Cardiovascular Clinical College & TEDA International Cardiovascular Hospital, Tianjin, China.

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Related in: MedlinePlus

Expressions of GAPDH, vWF, VEGF, IL-1β and TGF-β3 mRNA. (A) shows representative photos of electrophoresis. Qualitative analysis was performed by BandScan 5.0 software. The ratios of vWF, VEGF, IL-1β and TGF-β3 to GAPDH were compared in (B–E), respectively. *P < 0.05 versus control group. ♦P < 0.05 versus C group. ▾P < 0.001 versus TS group. GAPDH: glyceraldehyde-3-phosphate dehydrogenase; vWF: von Willebrand factor; VEGF: vascular endothelial growth factor; IL-1β: interleukin-1β; TGF-β3: transforming growth factor-β3.
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fig01: Expressions of GAPDH, vWF, VEGF, IL-1β and TGF-β3 mRNA. (A) shows representative photos of electrophoresis. Qualitative analysis was performed by BandScan 5.0 software. The ratios of vWF, VEGF, IL-1β and TGF-β3 to GAPDH were compared in (B–E), respectively. *P < 0.05 versus control group. ♦P < 0.05 versus C group. ▾P < 0.001 versus TS group. GAPDH: glyceraldehyde-3-phosphate dehydrogenase; vWF: von Willebrand factor; VEGF: vascular endothelial growth factor; IL-1β: interleukin-1β; TGF-β3: transforming growth factor-β3.

Mentions: Six weeks after treatment, semi-quantitative analysis of PCR product showed that the expression levels of vWF, VEGF, IL-1β and TGF-β3 mRNA in TSC group were significantly increased compared with control, C and TS groups, though those in C and TS groups also up-regulated relative to the control group (P < 0.05). (Fig. 1)


Mechanisms of the protective effects of BMSCs promoted by TMDR with heparinized bFGF-incorporated stent in pig model of acute myocardial ischemia.

Zhang GW, Liu XC, Li-Ling J, Luan Y, Ying YN, Wu XS, Zhao CH, Liu TJ, Lü F - J. Cell. Mol. Med. (2010)

Expressions of GAPDH, vWF, VEGF, IL-1β and TGF-β3 mRNA. (A) shows representative photos of electrophoresis. Qualitative analysis was performed by BandScan 5.0 software. The ratios of vWF, VEGF, IL-1β and TGF-β3 to GAPDH were compared in (B–E), respectively. *P < 0.05 versus control group. ♦P < 0.05 versus C group. ▾P < 0.001 versus TS group. GAPDH: glyceraldehyde-3-phosphate dehydrogenase; vWF: von Willebrand factor; VEGF: vascular endothelial growth factor; IL-1β: interleukin-1β; TGF-β3: transforming growth factor-β3.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3822621&req=5

fig01: Expressions of GAPDH, vWF, VEGF, IL-1β and TGF-β3 mRNA. (A) shows representative photos of electrophoresis. Qualitative analysis was performed by BandScan 5.0 software. The ratios of vWF, VEGF, IL-1β and TGF-β3 to GAPDH were compared in (B–E), respectively. *P < 0.05 versus control group. ♦P < 0.05 versus C group. ▾P < 0.001 versus TS group. GAPDH: glyceraldehyde-3-phosphate dehydrogenase; vWF: von Willebrand factor; VEGF: vascular endothelial growth factor; IL-1β: interleukin-1β; TGF-β3: transforming growth factor-β3.
Mentions: Six weeks after treatment, semi-quantitative analysis of PCR product showed that the expression levels of vWF, VEGF, IL-1β and TGF-β3 mRNA in TSC group were significantly increased compared with control, C and TS groups, though those in C and TS groups also up-regulated relative to the control group (P < 0.05). (Fig. 1)

Bottom Line: Autologous BMSCs were transplanted into the ischemic region in C group or around the channels in TSC group.Expression of von Willebrand factor, vascular endothelial growth factor, interleukin-1β, transforming growth factor-β(3) , cell proliferation and apoptosis, histological and morphological analyses, myocardial remodelling and cardiac function were evaluated at different time-points.Six weeks after the operation, the above indices were significantly improved in TSC group compared with others (P < 0.05), though C and TS groups also showed better results than the control group (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Tianjin Medical University Cardiovascular Clinical College & TEDA International Cardiovascular Hospital, Tianjin, China.

Show MeSH
Related in: MedlinePlus