Mechanisms of the protective effects of BMSCs promoted by TMDR with heparinized bFGF-incorporated stent in pig model of acute myocardial ischemia.
Bottom Line: Autologous BMSCs were transplanted into the ischemic region in C group or around the channels in TSC group.Expression of von Willebrand factor, vascular endothelial growth factor, interleukin-1β, transforming growth factor-β(3) , cell proliferation and apoptosis, histological and morphological analyses, myocardial remodelling and cardiac function were evaluated at different time-points.Six weeks after the operation, the above indices were significantly improved in TSC group compared with others (P < 0.05), though C and TS groups also showed better results than the control group (P < 0.05).
Affiliation: Department of Surgery, Tianjin Medical University Cardiovascular Clinical College & TEDA International Cardiovascular Hospital, Tianjin, China.Show MeSH
Related in: MedlinePlus
Mentions: Six weeks after treatment, semi-quantitative analysis of PCR product showed that the expression levels of vWF, VEGF, IL-1β and TGF-β3 mRNA in TSC group were significantly increased compared with control, C and TS groups, though those in C and TS groups also up-regulated relative to the control group (P < 0.05). (Fig. 1)
Affiliation: Department of Surgery, Tianjin Medical University Cardiovascular Clinical College & TEDA International Cardiovascular Hospital, Tianjin, China.