Molecular conformation changes along the malignancy revealed by optical nanosensors.
Bottom Line: Sensitive information originating from surrounding native biological molecules is provided by the tissue SERS spectra obtained either with visible or NIR laser line.Labelled nanoparticles introduced systematic differences in tissue response compared with unlabelled ones, suggesting that the label functional groups tag specific tissue components revealed by proteins or nucleic acids bands.The results obtained here open perspectives in applied plasmonic nanoparticles and SERS for the early cancer diagnostic based on the appropriate spectral databank.
Affiliation: Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Romania. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: Figure 5 presents a comparative resume of the tissue NIR-Raman and NIR-SERS spectra. The conventional NIR-Raman spectra of the formaline-preserved skin are compared with the NIR-SERS spectra collected from tissue with CV-labelled and -unlabelled Ag nanoparticles. The observed vibrational modes are synthesized in the Table 1 together with the proposed assignment.
Affiliation: Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Romania. firstname.lastname@example.org