Limits...
Molecular conformation changes along the malignancy revealed by optical nanosensors.

Cinta Pinzaru S, Falamas A, Dehelean CA - J. Cell. Mol. Med. (2013)

Bottom Line: Sensitive information originating from surrounding native biological molecules is provided by the tissue SERS spectra obtained either with visible or NIR laser line.Labelled nanoparticles introduced systematic differences in tissue response compared with unlabelled ones, suggesting that the label functional groups tag specific tissue components revealed by proteins or nucleic acids bands.The results obtained here open perspectives in applied plasmonic nanoparticles and SERS for the early cancer diagnostic based on the appropriate spectral databank.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Romania. simona.cinta@phys.ubbcluj.ro

Show MeSH

Related in: MedlinePlus

Comparative NIR-Raman and NIR-SERS spectra from the skin tissue (Balb/c): (A) SERS signature of the CV adsorbed on Ag nanoparticles, (B and C) SERS spectra of the labelled tissue at the surface and at 1 μm depth, respectively, (D) SERS spectra with unlabelled Ag nanoparticles and (E) Conventional Raman spectrum of the skin. Excitation 785 nm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3822590&req=5

fig05: Comparative NIR-Raman and NIR-SERS spectra from the skin tissue (Balb/c): (A) SERS signature of the CV adsorbed on Ag nanoparticles, (B and C) SERS spectra of the labelled tissue at the surface and at 1 μm depth, respectively, (D) SERS spectra with unlabelled Ag nanoparticles and (E) Conventional Raman spectrum of the skin. Excitation 785 nm.

Mentions: Figure 5 presents a comparative resume of the tissue NIR-Raman and NIR-SERS spectra. The conventional NIR-Raman spectra of the formaline-preserved skin are compared with the NIR-SERS spectra collected from tissue with CV-labelled and -unlabelled Ag nanoparticles. The observed vibrational modes are synthesized in the Table 1 together with the proposed assignment.


Molecular conformation changes along the malignancy revealed by optical nanosensors.

Cinta Pinzaru S, Falamas A, Dehelean CA - J. Cell. Mol. Med. (2013)

Comparative NIR-Raman and NIR-SERS spectra from the skin tissue (Balb/c): (A) SERS signature of the CV adsorbed on Ag nanoparticles, (B and C) SERS spectra of the labelled tissue at the surface and at 1 μm depth, respectively, (D) SERS spectra with unlabelled Ag nanoparticles and (E) Conventional Raman spectrum of the skin. Excitation 785 nm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3822590&req=5

fig05: Comparative NIR-Raman and NIR-SERS spectra from the skin tissue (Balb/c): (A) SERS signature of the CV adsorbed on Ag nanoparticles, (B and C) SERS spectra of the labelled tissue at the surface and at 1 μm depth, respectively, (D) SERS spectra with unlabelled Ag nanoparticles and (E) Conventional Raman spectrum of the skin. Excitation 785 nm.
Mentions: Figure 5 presents a comparative resume of the tissue NIR-Raman and NIR-SERS spectra. The conventional NIR-Raman spectra of the formaline-preserved skin are compared with the NIR-SERS spectra collected from tissue with CV-labelled and -unlabelled Ag nanoparticles. The observed vibrational modes are synthesized in the Table 1 together with the proposed assignment.

Bottom Line: Sensitive information originating from surrounding native biological molecules is provided by the tissue SERS spectra obtained either with visible or NIR laser line.Labelled nanoparticles introduced systematic differences in tissue response compared with unlabelled ones, suggesting that the label functional groups tag specific tissue components revealed by proteins or nucleic acids bands.The results obtained here open perspectives in applied plasmonic nanoparticles and SERS for the early cancer diagnostic based on the appropriate spectral databank.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Romania. simona.cinta@phys.ubbcluj.ro

Show MeSH
Related in: MedlinePlus