Molecular conformation changes along the malignancy revealed by optical nanosensors.
Bottom Line: Sensitive information originating from surrounding native biological molecules is provided by the tissue SERS spectra obtained either with visible or NIR laser line.Labelled nanoparticles introduced systematic differences in tissue response compared with unlabelled ones, suggesting that the label functional groups tag specific tissue components revealed by proteins or nucleic acids bands.The results obtained here open perspectives in applied plasmonic nanoparticles and SERS for the early cancer diagnostic based on the appropriate spectral databank.
Affiliation: Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Romania. email@example.comShow MeSH
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Mentions: Formalin-fixed tumour sections were H & E stained and analysed as histology samples and by application of S-100 and melan-A methods. Balb/c skin (week 14, Fig. 1A) revealed strong inflammatory process, the presence of oedematous dermis, hyperemiated blood vessels and chronically inflammatory infiltrate. The C57BL/6J mouse (B16 4A5 melanoma, Fig. 1C and D) revealed the diffusion of melanoma on skin level based on the E.S100 immunohistological confirmation.
Affiliation: Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Romania. firstname.lastname@example.org