Mechanobiology in cardiac physiology and diseases.
Bottom Line: Mechanosensitivity is essential for heart function just as for all other cells and organs in the body, and it is involved in both normal physiology and diseases processes of the cardiovascular system.We then focused on molecules involved in mechanotransduction, particularly mechanosensitive ion channels.Finally, mechanobiology in cardiogenesis is described with regard to regenerative medicine.
Affiliation: Department of Cardiovascular Physiology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. firstname.lastname@example.orgShow MeSH
Related in: MedlinePlus
Mentions: Like other general ion channels, mechanosensitive ion channels change their conformations and become permeable to ions in response to multiple types of stimuli. Conformational changes in ion channels in response to mechanical stimuli have been well studied for the bacterial mechanosensitive channel MscL (mechanosensitive channel of large conductance). An example of mechanosensitive opening of MscS (mechanosensitive channel of small conductance) by coarse-grained molecular dynamics simulation carried out in our laboratory is shown in Figure 2A. As in this simulation, certain types of ion channels change their conformation in response to bilayer tension. Other types of channels sense mechanical stimuli by the interaction with cytoskeletal elements.
Affiliation: Department of Cardiovascular Physiology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. email@example.com