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Mechanobiology in cardiac physiology and diseases.

Takahashi K, Kakimoto Y, Toda K, Naruse K - J. Cell. Mol. Med. (2013)

Bottom Line: Mechanosensitivity is essential for heart function just as for all other cells and organs in the body, and it is involved in both normal physiology and diseases processes of the cardiovascular system.We then focused on molecules involved in mechanotransduction, particularly mechanosensitive ion channels.Finally, mechanobiology in cardiogenesis is described with regard to regenerative medicine.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiovascular Physiology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. takah-k2@cc.okayama-u.ac.jp

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Structure of mechanosensitive ion channels. Upper panels: top views, lower panels: side views. (A) Opening of the bacterial mechanosensitive channel of small conductance (MscS, PDB accession number: 2OAU) in response to lipid bilayer stretch obtained by coarse-grained molecular dynamics simulation. MscS channel is embedded in lipid bilayers consisting of palmitoyloleoylphosphatidylcholine (POPC) and palmitoyloleoylphosphatidylethanolamine (POPE) lipids, which are shown in stick representation. The simulation box is filled with water molecules. Duration after applying a bilayer stretch is indicated in nanoseconds. Note that the channel's pore enlarges over time. (B) Three-dimensional crystal structure of mammalian Kv1.2 channel (PDB accession number: 3LUT) that putatively possesses mechanosensitivity.
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fig02: Structure of mechanosensitive ion channels. Upper panels: top views, lower panels: side views. (A) Opening of the bacterial mechanosensitive channel of small conductance (MscS, PDB accession number: 2OAU) in response to lipid bilayer stretch obtained by coarse-grained molecular dynamics simulation. MscS channel is embedded in lipid bilayers consisting of palmitoyloleoylphosphatidylcholine (POPC) and palmitoyloleoylphosphatidylethanolamine (POPE) lipids, which are shown in stick representation. The simulation box is filled with water molecules. Duration after applying a bilayer stretch is indicated in nanoseconds. Note that the channel's pore enlarges over time. (B) Three-dimensional crystal structure of mammalian Kv1.2 channel (PDB accession number: 3LUT) that putatively possesses mechanosensitivity.

Mentions: Like other general ion channels, mechanosensitive ion channels change their conformations and become permeable to ions in response to multiple types of stimuli. Conformational changes in ion channels in response to mechanical stimuli have been well studied for the bacterial mechanosensitive channel MscL (mechanosensitive channel of large conductance). An example of mechanosensitive opening of MscS (mechanosensitive channel of small conductance) by coarse-grained molecular dynamics simulation carried out in our laboratory is shown in Figure 2A. As in this simulation, certain types of ion channels change their conformation in response to bilayer tension. Other types of channels sense mechanical stimuli by the interaction with cytoskeletal elements.


Mechanobiology in cardiac physiology and diseases.

Takahashi K, Kakimoto Y, Toda K, Naruse K - J. Cell. Mol. Med. (2013)

Structure of mechanosensitive ion channels. Upper panels: top views, lower panels: side views. (A) Opening of the bacterial mechanosensitive channel of small conductance (MscS, PDB accession number: 2OAU) in response to lipid bilayer stretch obtained by coarse-grained molecular dynamics simulation. MscS channel is embedded in lipid bilayers consisting of palmitoyloleoylphosphatidylcholine (POPC) and palmitoyloleoylphosphatidylethanolamine (POPE) lipids, which are shown in stick representation. The simulation box is filled with water molecules. Duration after applying a bilayer stretch is indicated in nanoseconds. Note that the channel's pore enlarges over time. (B) Three-dimensional crystal structure of mammalian Kv1.2 channel (PDB accession number: 3LUT) that putatively possesses mechanosensitivity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3822585&req=5

fig02: Structure of mechanosensitive ion channels. Upper panels: top views, lower panels: side views. (A) Opening of the bacterial mechanosensitive channel of small conductance (MscS, PDB accession number: 2OAU) in response to lipid bilayer stretch obtained by coarse-grained molecular dynamics simulation. MscS channel is embedded in lipid bilayers consisting of palmitoyloleoylphosphatidylcholine (POPC) and palmitoyloleoylphosphatidylethanolamine (POPE) lipids, which are shown in stick representation. The simulation box is filled with water molecules. Duration after applying a bilayer stretch is indicated in nanoseconds. Note that the channel's pore enlarges over time. (B) Three-dimensional crystal structure of mammalian Kv1.2 channel (PDB accession number: 3LUT) that putatively possesses mechanosensitivity.
Mentions: Like other general ion channels, mechanosensitive ion channels change their conformations and become permeable to ions in response to multiple types of stimuli. Conformational changes in ion channels in response to mechanical stimuli have been well studied for the bacterial mechanosensitive channel MscL (mechanosensitive channel of large conductance). An example of mechanosensitive opening of MscS (mechanosensitive channel of small conductance) by coarse-grained molecular dynamics simulation carried out in our laboratory is shown in Figure 2A. As in this simulation, certain types of ion channels change their conformation in response to bilayer tension. Other types of channels sense mechanical stimuli by the interaction with cytoskeletal elements.

Bottom Line: Mechanosensitivity is essential for heart function just as for all other cells and organs in the body, and it is involved in both normal physiology and diseases processes of the cardiovascular system.We then focused on molecules involved in mechanotransduction, particularly mechanosensitive ion channels.Finally, mechanobiology in cardiogenesis is described with regard to regenerative medicine.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiovascular Physiology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. takah-k2@cc.okayama-u.ac.jp

Show MeSH
Related in: MedlinePlus