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Clinical relevance and functional implications for human leucocyte antigen-g expression in non-small-cell lung cancer.

Lin A, Zhu CC, Chen HX, Chen BF, Zhang X, Zhang JG, Wang Q, Zhou WJ, Hu W, Yang HH, Xu HH, Yan WH - J. Cell. Mol. Med. (2010)

Bottom Line: HLA-G has been documented both in establishment of anti-tumour immune responses and in tumour evasion.Patient plasma sHLA-G level (≥median, 32.0 U/ml) had a significantly shorter survival time (P= 0.044); however, no similar significance was observed for the lesion HLA-G expression.In vitro data showed that both cell surface HLA-G and patient plasma sHLA-G could dramatically decrease the NK cell cytolysis.

View Article: PubMed Central - PubMed

Affiliation: Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China.

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Kaplan–Meier estimates the survival curves for NSCLC patients with HLA-G expression in primary lesions (n= 51) or plasma sHLA-G (n= 67). (A) Patients with the sHLA-G above median level (32.0 U/ml) had a significantly shorter survival time than that with lower sHLA-G expression (P= 0.044). (B) No statistical significance was observed for the HLA-G expression in primary lesions and survival (P= 0.498).
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fig03: Kaplan–Meier estimates the survival curves for NSCLC patients with HLA-G expression in primary lesions (n= 51) or plasma sHLA-G (n= 67). (A) Patients with the sHLA-G above median level (32.0 U/ml) had a significantly shorter survival time than that with lower sHLA-G expression (P= 0.044). (B) No statistical significance was observed for the HLA-G expression in primary lesions and survival (P= 0.498).

Mentions: We next identified potential effects of both plasma sHLA-G (n= 67) and lesion HLA-G status (n= 51) on patient survival using the Kaplan–Meier method. Patients with the sHLA-G above median level (32.0 U/ml) had a significantly shorter survival time than those with lower sHLA-G expression (P= 0.044) (Fig. 3A). However, for the lesion HLA-G expression, no statistical significance was reached for the survival analysis (P= 0.498) (Fig. 3B).


Clinical relevance and functional implications for human leucocyte antigen-g expression in non-small-cell lung cancer.

Lin A, Zhu CC, Chen HX, Chen BF, Zhang X, Zhang JG, Wang Q, Zhou WJ, Hu W, Yang HH, Xu HH, Yan WH - J. Cell. Mol. Med. (2010)

Kaplan–Meier estimates the survival curves for NSCLC patients with HLA-G expression in primary lesions (n= 51) or plasma sHLA-G (n= 67). (A) Patients with the sHLA-G above median level (32.0 U/ml) had a significantly shorter survival time than that with lower sHLA-G expression (P= 0.044). (B) No statistical significance was observed for the HLA-G expression in primary lesions and survival (P= 0.498).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3822572&req=5

fig03: Kaplan–Meier estimates the survival curves for NSCLC patients with HLA-G expression in primary lesions (n= 51) or plasma sHLA-G (n= 67). (A) Patients with the sHLA-G above median level (32.0 U/ml) had a significantly shorter survival time than that with lower sHLA-G expression (P= 0.044). (B) No statistical significance was observed for the HLA-G expression in primary lesions and survival (P= 0.498).
Mentions: We next identified potential effects of both plasma sHLA-G (n= 67) and lesion HLA-G status (n= 51) on patient survival using the Kaplan–Meier method. Patients with the sHLA-G above median level (32.0 U/ml) had a significantly shorter survival time than those with lower sHLA-G expression (P= 0.044) (Fig. 3A). However, for the lesion HLA-G expression, no statistical significance was reached for the survival analysis (P= 0.498) (Fig. 3B).

Bottom Line: HLA-G has been documented both in establishment of anti-tumour immune responses and in tumour evasion.Patient plasma sHLA-G level (≥median, 32.0 U/ml) had a significantly shorter survival time (P= 0.044); however, no similar significance was observed for the lesion HLA-G expression.In vitro data showed that both cell surface HLA-G and patient plasma sHLA-G could dramatically decrease the NK cell cytolysis.

View Article: PubMed Central - PubMed

Affiliation: Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China.

Show MeSH
Related in: MedlinePlus