Clinical relevance and functional implications for human leucocyte antigen-g expression in non-small-cell lung cancer.
Bottom Line: HLA-G has been documented both in establishment of anti-tumour immune responses and in tumour evasion.Patient plasma sHLA-G level (≥median, 32.0 U/ml) had a significantly shorter survival time (P= 0.044); however, no similar significance was observed for the lesion HLA-G expression.In vitro data showed that both cell surface HLA-G and patient plasma sHLA-G could dramatically decrease the NK cell cytolysis.
Affiliation: Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China.Show MeSH
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Mentions: We next identified potential effects of both plasma sHLA-G (n= 67) and lesion HLA-G status (n= 51) on patient survival using the Kaplan–Meier method. Patients with the sHLA-G above median level (32.0 U/ml) had a significantly shorter survival time than those with lower sHLA-G expression (P= 0.044) (Fig. 3A). However, for the lesion HLA-G expression, no statistical significance was reached for the survival analysis (P= 0.498) (Fig. 3B).
Affiliation: Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China.