Clinical relevance and functional implications for human leucocyte antigen-g expression in non-small-cell lung cancer.
Bottom Line: HLA-G has been documented both in establishment of anti-tumour immune responses and in tumour evasion.Patient plasma sHLA-G level (≥median, 32.0 U/ml) had a significantly shorter survival time (P= 0.044); however, no similar significance was observed for the lesion HLA-G expression.In vitro data showed that both cell surface HLA-G and patient plasma sHLA-G could dramatically decrease the NK cell cytolysis.
Affiliation: Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China.Show MeSH
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Mentions: Plasma sHLA-G levels in 91 NSCLC patients and 150 normal healthy individuals were determined by ELISA. Concentration of the plasma sHLA-G was with the median of 34.0 U/ml (range: 3.13– 275.5) for NSCLC patients, 20.4 U/ml (range: 0.97–270.6) for normal controls, respectively. Data revealed that sHLA-G expression in NSCLC patients was significantly higher than that in normal controls (P= 0.004) (Fig. 2A).
Affiliation: Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China.