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Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation.

Swan DJ, Kirby JA, Ali S - J. Cell. Mol. Med. (2010)

Bottom Line: The vascular and immune systems of mammals are closely intertwined: the individual components of the immune system must move between various body compartments to perform their function effectively.Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, exerts effects on the two organ systems and influences the interaction between them.The latter part concerns crosstalk between S1P and other signalling pathways, and concludes with a look at therapies targeting the S1P-S1P receptor axis.

View Article: PubMed Central - PubMed

Affiliation: Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK.

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Related in: MedlinePlus

Synthesis, degradation and molecular structure of S1P. S1P is formed either de novo, from serine, palmitoyl coA and a fatty acid, or from the breakdown of membrane-resident sphingomyelin. S1P can be dephosphorylated, reversibly, to sphingosine, or degraded irreversibly to phosphoethanolamine and hexadecanal.
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fig02: Synthesis, degradation and molecular structure of S1P. S1P is formed either de novo, from serine, palmitoyl coA and a fatty acid, or from the breakdown of membrane-resident sphingomyelin. S1P can be dephosphorylated, reversibly, to sphingosine, or degraded irreversibly to phosphoethanolamine and hexadecanal.

Mentions: S1P is a bioactive lipid and member of the lysophospholipid family. It is 379 Da in size and consists of a polar head group and a long saturated aliphatic tail (Fig. 2).


Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation.

Swan DJ, Kirby JA, Ali S - J. Cell. Mol. Med. (2010)

Synthesis, degradation and molecular structure of S1P. S1P is formed either de novo, from serine, palmitoyl coA and a fatty acid, or from the breakdown of membrane-resident sphingomyelin. S1P can be dephosphorylated, reversibly, to sphingosine, or degraded irreversibly to phosphoethanolamine and hexadecanal.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3822560&req=5

fig02: Synthesis, degradation and molecular structure of S1P. S1P is formed either de novo, from serine, palmitoyl coA and a fatty acid, or from the breakdown of membrane-resident sphingomyelin. S1P can be dephosphorylated, reversibly, to sphingosine, or degraded irreversibly to phosphoethanolamine and hexadecanal.
Mentions: S1P is a bioactive lipid and member of the lysophospholipid family. It is 379 Da in size and consists of a polar head group and a long saturated aliphatic tail (Fig. 2).

Bottom Line: The vascular and immune systems of mammals are closely intertwined: the individual components of the immune system must move between various body compartments to perform their function effectively.Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, exerts effects on the two organ systems and influences the interaction between them.The latter part concerns crosstalk between S1P and other signalling pathways, and concludes with a look at therapies targeting the S1P-S1P receptor axis.

View Article: PubMed Central - PubMed

Affiliation: Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK.

Show MeSH
Related in: MedlinePlus