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Diffuse nesidioblastosis diagnosed on a Ga-68 DOTATATE positron emission tomography/computerized tomography.

Arun S, Rai Mittal B, Shukla J, Bhattacharya A, Kumar P - Indian J Nucl Med (2013)

Bottom Line: The authors describe a 50 days old pre-term infant with persistent hyperinsulinemic hypoglycemia of infancy in whom Ga-68 DOTATATE positron emission tomography/computerized tomography scan showed diffusely increased tracer uptake in the entire pancreas with no abnormal tracer uptake anywhere else in the body, suggestive of a diffuse variant of nesidioblastosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine and PET, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

ABSTRACT
The authors describe a 50 days old pre-term infant with persistent hyperinsulinemic hypoglycemia of infancy in whom Ga-68 DOTATATE positron emission tomography/computerized tomography scan showed diffusely increased tracer uptake in the entire pancreas with no abnormal tracer uptake anywhere else in the body, suggestive of a diffuse variant of nesidioblastosis.

No MeSH data available.


Related in: MedlinePlus

Ga-68 DOTATATE positron emission tomography/computed tomography (CT) (a) Maximum intensity projection (b) transaxial CT (c) transaxial fused images showing diffusely increased tracer uptake in the entire pancreas (arrow) with no abnormal tracer uptake elsewhere in the body, suggestive of a diffuse variant of nesidioblastosis
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Figure 1: Ga-68 DOTATATE positron emission tomography/computed tomography (CT) (a) Maximum intensity projection (b) transaxial CT (c) transaxial fused images showing diffusely increased tracer uptake in the entire pancreas (arrow) with no abnormal tracer uptake elsewhere in the body, suggestive of a diffuse variant of nesidioblastosis

Mentions: A 50-day-old pre-term female infant presented with persistent hyperinsulinemic hypoglycemia. The child was born at 35 weeks of gestation, with breathing difficulty since birth. She developed cyanosis on day 2 of life with seizures thereafter. On investigation the child was found to be hypoglycemia (blood glucose level = 16.8 mg/dl) and hyperinsulinemia with serum insulin levels of 149.70 IU/ml (n = 2.0 IU/ml). Screening for sepsis was negative. The child required intravenous glucose infusion up to 10 mg/kg/min and oral feeds fortified with glucose to maintain euglycemic state. Ga-68 DOTATATE positron emission tomography/computerized tomography (PET/CT) scan showed diffusely increased tracer uptake in the entire pancreas with no abnormal tracer uptake anywhere else in the body, suggestive of a diffuse variant of nesidioblastosis [Figure 1]. The child is currently on injection octreotide but not fit for definitive surgical management (near total pancreatectomy).


Diffuse nesidioblastosis diagnosed on a Ga-68 DOTATATE positron emission tomography/computerized tomography.

Arun S, Rai Mittal B, Shukla J, Bhattacharya A, Kumar P - Indian J Nucl Med (2013)

Ga-68 DOTATATE positron emission tomography/computed tomography (CT) (a) Maximum intensity projection (b) transaxial CT (c) transaxial fused images showing diffusely increased tracer uptake in the entire pancreas (arrow) with no abnormal tracer uptake elsewhere in the body, suggestive of a diffuse variant of nesidioblastosis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3822415&req=5

Figure 1: Ga-68 DOTATATE positron emission tomography/computed tomography (CT) (a) Maximum intensity projection (b) transaxial CT (c) transaxial fused images showing diffusely increased tracer uptake in the entire pancreas (arrow) with no abnormal tracer uptake elsewhere in the body, suggestive of a diffuse variant of nesidioblastosis
Mentions: A 50-day-old pre-term female infant presented with persistent hyperinsulinemic hypoglycemia. The child was born at 35 weeks of gestation, with breathing difficulty since birth. She developed cyanosis on day 2 of life with seizures thereafter. On investigation the child was found to be hypoglycemia (blood glucose level = 16.8 mg/dl) and hyperinsulinemia with serum insulin levels of 149.70 IU/ml (n = 2.0 IU/ml). Screening for sepsis was negative. The child required intravenous glucose infusion up to 10 mg/kg/min and oral feeds fortified with glucose to maintain euglycemic state. Ga-68 DOTATATE positron emission tomography/computerized tomography (PET/CT) scan showed diffusely increased tracer uptake in the entire pancreas with no abnormal tracer uptake anywhere else in the body, suggestive of a diffuse variant of nesidioblastosis [Figure 1]. The child is currently on injection octreotide but not fit for definitive surgical management (near total pancreatectomy).

Bottom Line: The authors describe a 50 days old pre-term infant with persistent hyperinsulinemic hypoglycemia of infancy in whom Ga-68 DOTATATE positron emission tomography/computerized tomography scan showed diffusely increased tracer uptake in the entire pancreas with no abnormal tracer uptake anywhere else in the body, suggestive of a diffuse variant of nesidioblastosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine and PET, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

ABSTRACT
The authors describe a 50 days old pre-term infant with persistent hyperinsulinemic hypoglycemia of infancy in whom Ga-68 DOTATATE positron emission tomography/computerized tomography scan showed diffusely increased tracer uptake in the entire pancreas with no abnormal tracer uptake anywhere else in the body, suggestive of a diffuse variant of nesidioblastosis.

No MeSH data available.


Related in: MedlinePlus