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Peripheral primitive neuroectodermal tumor of the adrenal gland: A rare entity.

Phukan C, Nirmal TJ, Kumar RM, Kekre NS - Indian J Urol (2013)

Bottom Line: A 37-year-old female was evaluated for an episode of loin pain.Ultrasonography showed a large heterogenous left adrenal mass with internal echogenic components.Computed tomography did not show any fat density within to suggest a myelolipoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Christian Medical College, Tamil Nadu, Vellore, India.

ABSTRACT
Peripheral primitive neuroectodermal tumor (PNET) is an uncommon tumor and the overall incidence is 1% of all sarcomas. PNET of the adrenal gland is an even rarer entity. A 37-year-old female was evaluated for an episode of loin pain. Ultrasonography showed a large heterogenous left adrenal mass with internal echogenic components. Computed tomography did not show any fat density within to suggest a myelolipoma. Biopsy suggested a poorly differentiated neoplasm with a possibility of PNET of the adrenal gland.

No MeSH data available.


Related in: MedlinePlus

H and E, ×20, medium-sized round cells with round to oval vesicular nuclei exhibiting mitoses and containing scant to moderate cytoplasm
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Figure 3: H and E, ×20, medium-sized round cells with round to oval vesicular nuclei exhibiting mitoses and containing scant to moderate cytoplasm

Mentions: Gross specimen showed a 12 × 10 × 8 cm left adrenal mass, infiltrating the left kidney. Cut section showed hemorrhagic and necrosed adrenal mass adherent to the kidney [Figure 2]. Microscopy showed a predominantly necrotic and hemorrhagic tumor with few viable areas composed of diffuse sheets of small to medium sized round cells with round to oval vesicular nuclei exhibiting mitoses up to 10-15/50 hpf and containing scant to moderate cytoplasm. The tumor cell nests infiltrated the thick fibrous capsule and extended into the pericapsular adipose tissue. There were foci of vascular invasion [Figure 3]. Immunohistological staining using CD 99 showed strong positivity [Figure 4]. There was weak positivity with FLI 1, in at least 50% of cells [Figure 5].


Peripheral primitive neuroectodermal tumor of the adrenal gland: A rare entity.

Phukan C, Nirmal TJ, Kumar RM, Kekre NS - Indian J Urol (2013)

H and E, ×20, medium-sized round cells with round to oval vesicular nuclei exhibiting mitoses and containing scant to moderate cytoplasm
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3822357&req=5

Figure 3: H and E, ×20, medium-sized round cells with round to oval vesicular nuclei exhibiting mitoses and containing scant to moderate cytoplasm
Mentions: Gross specimen showed a 12 × 10 × 8 cm left adrenal mass, infiltrating the left kidney. Cut section showed hemorrhagic and necrosed adrenal mass adherent to the kidney [Figure 2]. Microscopy showed a predominantly necrotic and hemorrhagic tumor with few viable areas composed of diffuse sheets of small to medium sized round cells with round to oval vesicular nuclei exhibiting mitoses up to 10-15/50 hpf and containing scant to moderate cytoplasm. The tumor cell nests infiltrated the thick fibrous capsule and extended into the pericapsular adipose tissue. There were foci of vascular invasion [Figure 3]. Immunohistological staining using CD 99 showed strong positivity [Figure 4]. There was weak positivity with FLI 1, in at least 50% of cells [Figure 5].

Bottom Line: A 37-year-old female was evaluated for an episode of loin pain.Ultrasonography showed a large heterogenous left adrenal mass with internal echogenic components.Computed tomography did not show any fat density within to suggest a myelolipoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Christian Medical College, Tamil Nadu, Vellore, India.

ABSTRACT
Peripheral primitive neuroectodermal tumor (PNET) is an uncommon tumor and the overall incidence is 1% of all sarcomas. PNET of the adrenal gland is an even rarer entity. A 37-year-old female was evaluated for an episode of loin pain. Ultrasonography showed a large heterogenous left adrenal mass with internal echogenic components. Computed tomography did not show any fat density within to suggest a myelolipoma. Biopsy suggested a poorly differentiated neoplasm with a possibility of PNET of the adrenal gland.

No MeSH data available.


Related in: MedlinePlus