Limits...
Relationship between serum osteocalcin levels and non-alcoholic fatty liver disease in adult males, South China.

Liu JJ, Chen YY, Mo ZN, Tian GX, Tan AH, Gao Y, Yang XB, Zhang HY, Li ZX - Int J Mol Sci (2013)

Bottom Line: Serum osteocalin level was associated with the scale of NAFLD (r = -0.150, p < 0.01).Serum osteocalin level tended to decrease with the scale of NAFLD.Binary logistic regression analysis showed that decreased ORs for NAFLD were observed from the first to the fourth osteocalcin quartiles.

View Article: PubMed Central - PubMed

Affiliation: Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. zhixianli@foxmail.com.

ABSTRACT

Aim: To determine serum osteocalcin levels in South Chinese males with non-alcoholic fatty liver disease (NAFLD) and to examine the relation between serum osteocalcin and NAFLD.

Methods: Data were collected from 1683 men attending the Fangchenggang Area Male Healthy and Examination Survey (FAMHES) from September 2009 to December 2009. Serum osteocalcin was measured with electrochemiluminescence immunoassay. An abdominal ultrasonographic examination for all individuals was performed by two experienced ultrasonographers. The associations of serum osteocalcin with NAFLD were evaluated.

Results: The levels of serum osteocalcin were lower in 364 NAFLD participants than in 1319 non-NAFLD participants (24.51 ± 1.38 ng/mL vs. 20.81 ± 1.33 ng/mL, p < 0.001). Serum osteocalin level was associated with the scale of NAFLD (r = -0.150, p < 0.01). Serum osteocalin level tended to decrease with the scale of NAFLD. Binary logistic regression analysis showed that decreased ORs for NAFLD were observed from the first to the fourth osteocalcin quartiles.

Conclusions: Our findings suggest that a lower serum osteocalcin level is associated with the presence of NAFLD.

Show MeSH

Related in: MedlinePlus

Prevalence of non-alcoholic fatty liver disease (NAFLD) in different quartiles of osteocalcin. The prevalence of NAFLD from the lowest to highest osteocalcin quartile were 30.62%, 26.95%, 20.19%, 9.26%, respectively (p < 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3821586&req=5

f1-ijms-14-19782: Prevalence of non-alcoholic fatty liver disease (NAFLD) in different quartiles of osteocalcin. The prevalence of NAFLD from the lowest to highest osteocalcin quartile were 30.62%, 26.95%, 20.19%, 9.26%, respectively (p < 0.001).

Mentions: Participants with lower serum osteocalcin levels might be suffer from NAFLD. The prevalence of NAFLD of different quartiles was shown in Figure 1. The prevalence of NAFLD from the lowest to highest osteocalcin quartile were 30.62%, 26.95%, 20.19%, 9.26%, respectively (p < 0.001). The binary logistic regression analysis results were shown in Table 3. Decreased ORs for NAFLD were observed from the first to the fourth osteocalcin quartiles. Compared with the subjects in the fourth osteocalcin quartile, those in the first quartile had an OR of 4.32 (95% confidence interval (CI), 2.93–6.38); those in the second quartile had an OR of 3.54 (CI, 2.39–5.25) and those in the third quartile had an OR of 2.47 (CI, 1.65–3.71).


Relationship between serum osteocalcin levels and non-alcoholic fatty liver disease in adult males, South China.

Liu JJ, Chen YY, Mo ZN, Tian GX, Tan AH, Gao Y, Yang XB, Zhang HY, Li ZX - Int J Mol Sci (2013)

Prevalence of non-alcoholic fatty liver disease (NAFLD) in different quartiles of osteocalcin. The prevalence of NAFLD from the lowest to highest osteocalcin quartile were 30.62%, 26.95%, 20.19%, 9.26%, respectively (p < 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3821586&req=5

f1-ijms-14-19782: Prevalence of non-alcoholic fatty liver disease (NAFLD) in different quartiles of osteocalcin. The prevalence of NAFLD from the lowest to highest osteocalcin quartile were 30.62%, 26.95%, 20.19%, 9.26%, respectively (p < 0.001).
Mentions: Participants with lower serum osteocalcin levels might be suffer from NAFLD. The prevalence of NAFLD of different quartiles was shown in Figure 1. The prevalence of NAFLD from the lowest to highest osteocalcin quartile were 30.62%, 26.95%, 20.19%, 9.26%, respectively (p < 0.001). The binary logistic regression analysis results were shown in Table 3. Decreased ORs for NAFLD were observed from the first to the fourth osteocalcin quartiles. Compared with the subjects in the fourth osteocalcin quartile, those in the first quartile had an OR of 4.32 (95% confidence interval (CI), 2.93–6.38); those in the second quartile had an OR of 3.54 (CI, 2.39–5.25) and those in the third quartile had an OR of 2.47 (CI, 1.65–3.71).

Bottom Line: Serum osteocalin level was associated with the scale of NAFLD (r = -0.150, p < 0.01).Serum osteocalin level tended to decrease with the scale of NAFLD.Binary logistic regression analysis showed that decreased ORs for NAFLD were observed from the first to the fourth osteocalcin quartiles.

View Article: PubMed Central - PubMed

Affiliation: Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. zhixianli@foxmail.com.

ABSTRACT

Aim: To determine serum osteocalcin levels in South Chinese males with non-alcoholic fatty liver disease (NAFLD) and to examine the relation between serum osteocalcin and NAFLD.

Methods: Data were collected from 1683 men attending the Fangchenggang Area Male Healthy and Examination Survey (FAMHES) from September 2009 to December 2009. Serum osteocalcin was measured with electrochemiluminescence immunoassay. An abdominal ultrasonographic examination for all individuals was performed by two experienced ultrasonographers. The associations of serum osteocalcin with NAFLD were evaluated.

Results: The levels of serum osteocalcin were lower in 364 NAFLD participants than in 1319 non-NAFLD participants (24.51 ± 1.38 ng/mL vs. 20.81 ± 1.33 ng/mL, p < 0.001). Serum osteocalin level was associated with the scale of NAFLD (r = -0.150, p < 0.01). Serum osteocalin level tended to decrease with the scale of NAFLD. Binary logistic regression analysis showed that decreased ORs for NAFLD were observed from the first to the fourth osteocalcin quartiles.

Conclusions: Our findings suggest that a lower serum osteocalcin level is associated with the presence of NAFLD.

Show MeSH
Related in: MedlinePlus