Cross-talk of global nutritional regulators in the control of primary and secondary metabolism in Streptomyces.
Bottom Line: This regulation allows a 'metabolic homeostasis' of phosphate and nitrogen utilization pathways, preventing nutritional unbalances.Transport of N-acetylglucosamine by the NagE2 permease and, therefore, regulation of secondary metabolism, is dependent upon the balance of phosphorylated/dephosphorylated proteins of the N-acetylglucosamine phosphotransferase system.These findings provide the bases for understanding the mechanisms underlying systems biology of Streptomyces species.
Affiliation: INBIOTEC, Instituto de Biotecnología de León, Avda. Real n°. 1, Parque Científico de León, 24006 León, Spain. firstname.lastname@example.orgShow MeSH
Mentions: Other genes encoding putative phosphate scavengers are SCO1906, SCO3790 and SCO4152. Both SCO1906 and SCO3790 encode putative secreted phosphatases (other than PhoA and PhoC) and their promoters are bound by PhoP (Rodríguez‐García et al., 2007; Sola‐Landa et al., 2008) (Fig. 1). SCO4152 encodes a putative secreted 5′‐nucleotidase that is upregulated in the wild‐type transcriptome after phosphate shift‐down, but not in a ΔphoP mutant. Therefore, this gene is a candidate member of the pho regulon.
Affiliation: INBIOTEC, Instituto de Biotecnología de León, Avda. Real n°. 1, Parque Científico de León, 24006 León, Spain. email@example.com