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Risk of Atherosclerosis and Helicobacter pylori Infection according to CD14 Promotor Polymorphism in Healthy Korean Population.

Kang SG, Chung WC, Song SW, Joo KR, Lee H, Kang D, Lee JS, Lee KM - Gastroenterol Res Pract (2013)

Bottom Line: The genotype frequencies were CC 7.9%, CT 45.1%, and TT 47.0%, respectively.As for HDL cholesterol level, there were significant differences among the three genotypes (P < 0.01).Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93-6 Jungbu-daero, Paldal-gu, Suwon 442-723, Republic of Korea.

ABSTRACT
Background and Aim. We aim to elucidate the association of risk factors for atherosclerosis and H. pylori infection according to the promotor polymorphism of the CD14 gene in healthy Korean population. Methods. The patients who visited our hospital for routine health examinations and 266 healthy adults (170 males and 96 females) were enrolled in this study. The promotor polymorphism at -159C/T of the CD14 gene was determined by PCR-restriction fragment length polymorphism analysis. According to genetic polymorphism and H. pylori infection, we analyzed the risk of atherosclerosis. Results. The genotype frequencies were CC 7.9%, CT 45.1%, and TT 47.0%, respectively. There were no differences between specific genotypes of CD14 gene and H. pylori infection rate. As for HDL cholesterol level, there were significant differences among the three genotypes (P < 0.01). In subjects with H. pylori infection, no significant differences were observed between specific genotypes of CD14 gene and the risk factors of atherosclerosis. Conclusion. The promotor polymorphism at -159C/T of the CD14 gene was associated with the risk factor of atherosclerosis in healthy Korean population. However, it was not associated with the rate of H. pylori infection and H. pylori induced atherosclerotic risk.

No MeSH data available.


Related in: MedlinePlus

Detection of the −159C/T polymorphism of CD14 gene by using PCR-RFLP. Digestion of the PCR products yielded bands of 295 bp in TT homozygotes, 140 and 155 bp in CC homozygotes, and all 3 bands (140, 155, and 295 bp) in heterozygotes.
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Related In: Results  -  Collection


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fig1: Detection of the −159C/T polymorphism of CD14 gene by using PCR-RFLP. Digestion of the PCR products yielded bands of 295 bp in TT homozygotes, 140 and 155 bp in CC homozygotes, and all 3 bands (140, 155, and 295 bp) in heterozygotes.

Mentions: Digestion of the PCR products for the promoter polymorphism at −159C/T of the CD14 gene yielded bands of 295 bp in TT homozygotes, 140 and 155 bp in CC homozygotes, and all 3 bands (140, 155, and 295 bp) in heterozygotes (Figure 1). The genotype frequencies were CC 7.9%, CT 45.1%, and TT 47.0%, respectively. There were no differences in age, sex, the ratio of smokers, and alcohol drinkers between the three genotypes.


Risk of Atherosclerosis and Helicobacter pylori Infection according to CD14 Promotor Polymorphism in Healthy Korean Population.

Kang SG, Chung WC, Song SW, Joo KR, Lee H, Kang D, Lee JS, Lee KM - Gastroenterol Res Pract (2013)

Detection of the −159C/T polymorphism of CD14 gene by using PCR-RFLP. Digestion of the PCR products yielded bands of 295 bp in TT homozygotes, 140 and 155 bp in CC homozygotes, and all 3 bands (140, 155, and 295 bp) in heterozygotes.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3818843&req=5

fig1: Detection of the −159C/T polymorphism of CD14 gene by using PCR-RFLP. Digestion of the PCR products yielded bands of 295 bp in TT homozygotes, 140 and 155 bp in CC homozygotes, and all 3 bands (140, 155, and 295 bp) in heterozygotes.
Mentions: Digestion of the PCR products for the promoter polymorphism at −159C/T of the CD14 gene yielded bands of 295 bp in TT homozygotes, 140 and 155 bp in CC homozygotes, and all 3 bands (140, 155, and 295 bp) in heterozygotes (Figure 1). The genotype frequencies were CC 7.9%, CT 45.1%, and TT 47.0%, respectively. There were no differences in age, sex, the ratio of smokers, and alcohol drinkers between the three genotypes.

Bottom Line: The genotype frequencies were CC 7.9%, CT 45.1%, and TT 47.0%, respectively.As for HDL cholesterol level, there were significant differences among the three genotypes (P < 0.01).Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93-6 Jungbu-daero, Paldal-gu, Suwon 442-723, Republic of Korea.

ABSTRACT
Background and Aim. We aim to elucidate the association of risk factors for atherosclerosis and H. pylori infection according to the promotor polymorphism of the CD14 gene in healthy Korean population. Methods. The patients who visited our hospital for routine health examinations and 266 healthy adults (170 males and 96 females) were enrolled in this study. The promotor polymorphism at -159C/T of the CD14 gene was determined by PCR-restriction fragment length polymorphism analysis. According to genetic polymorphism and H. pylori infection, we analyzed the risk of atherosclerosis. Results. The genotype frequencies were CC 7.9%, CT 45.1%, and TT 47.0%, respectively. There were no differences between specific genotypes of CD14 gene and H. pylori infection rate. As for HDL cholesterol level, there were significant differences among the three genotypes (P < 0.01). In subjects with H. pylori infection, no significant differences were observed between specific genotypes of CD14 gene and the risk factors of atherosclerosis. Conclusion. The promotor polymorphism at -159C/T of the CD14 gene was associated with the risk factor of atherosclerosis in healthy Korean population. However, it was not associated with the rate of H. pylori infection and H. pylori induced atherosclerotic risk.

No MeSH data available.


Related in: MedlinePlus