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The presentation, pathology, and current management strategies of cutaneous metastasis.

Wong CY, Helm MA, Kalb RE, Helm TN, Zeitouni NC - N Am J Med Sci (2013)

Bottom Line: Our own clinical findings are presented and compared to the literature.Additionally, we highlight the most useful immunohistochemical studies that aid in diagnoses.Several novel therapies and combination therapies such as electrochemotherapy, vemurafenib, and imiquimod will be discussed for palliative treatment of cancers that have been found to improve cutaneous lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Roswell Park Cancer Institute, University at Buffalo, Buffalo, New York, USA.

ABSTRACT
Skin metastases are rare in the routine clinical practice of dermatology, but are of major clinical significance because they usually indicate advanced disease. We reviewed the literature on skin metastasis regarding recent trends in clinical presentation and diagnosis of the most common cutaneous lesions. An extensive literature review was conducted using PubMed from May 26, 2011 to July 16, 2013 relating cutaneous metastases. Articles chosen for reference were queried with the following prompts: "Cutaneous metastases", "clinical presentation", "histological features", and "immunohistochemistry". Further searches included "treatment" and "management" options for "metastatic breast", "metastatic colorectal", "metastatic melanoma", "metastatic lung", and "hematologic cancers." We also reviewed the literature on the current management of melanoma as a model for all cutaneous metastatic disease. Our own clinical findings are presented and compared to the literature. Additionally, we highlight the most useful immunohistochemical studies that aid in diagnoses. Several novel therapies and combination therapies such as electrochemotherapy, vemurafenib, and imiquimod will be discussed for palliative treatment of cancers that have been found to improve cutaneous lesions. We review these notable findings and developments regarding skin metastases for the general dermatologist.

No MeSH data available.


Related in: MedlinePlus

(a) Cellulitis-like appearance of metastatic breast cancer.(b) Plaque-like area with multiple nodules from a primary breast cancer. (c) Massive recurrence of breast cancer on the chest wall and abdomen of the “en cuirasse” type. (d) Breast cancer, metastatic to the thoracic spine with extension to the skin, and lceration secondary to radiation therapy
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Figure 2: (a) Cellulitis-like appearance of metastatic breast cancer.(b) Plaque-like area with multiple nodules from a primary breast cancer. (c) Massive recurrence of breast cancer on the chest wall and abdomen of the “en cuirasse” type. (d) Breast cancer, metastatic to the thoracic spine with extension to the skin, and lceration secondary to radiation therapy

Mentions: Metastases originating from breast cancer tend to appear in the anterior chest wall, either from direct extension of underlying tumor or by lymphatic spread [Figures 2a and 3a]. Extensive cutaneous involvement of metastatic breast cancer can simulate cellulitis (carcinoma erysipeloides) or a breast-plate of armor ("en cuirasse" pattern). Interestingly, a subset of breast cancer patients has superior prognosis, even among breast cancer patients with stage IV disease.[10]


The presentation, pathology, and current management strategies of cutaneous metastasis.

Wong CY, Helm MA, Kalb RE, Helm TN, Zeitouni NC - N Am J Med Sci (2013)

(a) Cellulitis-like appearance of metastatic breast cancer.(b) Plaque-like area with multiple nodules from a primary breast cancer. (c) Massive recurrence of breast cancer on the chest wall and abdomen of the “en cuirasse” type. (d) Breast cancer, metastatic to the thoracic spine with extension to the skin, and lceration secondary to radiation therapy
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3818821&req=5

Figure 2: (a) Cellulitis-like appearance of metastatic breast cancer.(b) Plaque-like area with multiple nodules from a primary breast cancer. (c) Massive recurrence of breast cancer on the chest wall and abdomen of the “en cuirasse” type. (d) Breast cancer, metastatic to the thoracic spine with extension to the skin, and lceration secondary to radiation therapy
Mentions: Metastases originating from breast cancer tend to appear in the anterior chest wall, either from direct extension of underlying tumor or by lymphatic spread [Figures 2a and 3a]. Extensive cutaneous involvement of metastatic breast cancer can simulate cellulitis (carcinoma erysipeloides) or a breast-plate of armor ("en cuirasse" pattern). Interestingly, a subset of breast cancer patients has superior prognosis, even among breast cancer patients with stage IV disease.[10]

Bottom Line: Our own clinical findings are presented and compared to the literature.Additionally, we highlight the most useful immunohistochemical studies that aid in diagnoses.Several novel therapies and combination therapies such as electrochemotherapy, vemurafenib, and imiquimod will be discussed for palliative treatment of cancers that have been found to improve cutaneous lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Roswell Park Cancer Institute, University at Buffalo, Buffalo, New York, USA.

ABSTRACT
Skin metastases are rare in the routine clinical practice of dermatology, but are of major clinical significance because they usually indicate advanced disease. We reviewed the literature on skin metastasis regarding recent trends in clinical presentation and diagnosis of the most common cutaneous lesions. An extensive literature review was conducted using PubMed from May 26, 2011 to July 16, 2013 relating cutaneous metastases. Articles chosen for reference were queried with the following prompts: "Cutaneous metastases", "clinical presentation", "histological features", and "immunohistochemistry". Further searches included "treatment" and "management" options for "metastatic breast", "metastatic colorectal", "metastatic melanoma", "metastatic lung", and "hematologic cancers." We also reviewed the literature on the current management of melanoma as a model for all cutaneous metastatic disease. Our own clinical findings are presented and compared to the literature. Additionally, we highlight the most useful immunohistochemical studies that aid in diagnoses. Several novel therapies and combination therapies such as electrochemotherapy, vemurafenib, and imiquimod will be discussed for palliative treatment of cancers that have been found to improve cutaneous lesions. We review these notable findings and developments regarding skin metastases for the general dermatologist.

No MeSH data available.


Related in: MedlinePlus