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Association of 3-Dimensional Cartilage and Bone Structure with Articular Cartilage Properties in and Adjacent to Autologous Osteochondral Grafts after 6 and 12 months in a Goat Model.

Chan EF, Liu IL, Semler EJ, Aberman HM, Simon TM, Chen AC, Truncale KG, Sah RL - Cartilage (2012)

Bottom Line: Operated MFC articular surfaces were recessed relative to Non-Operated MFC and exhibited lower cartilage stiffness with increasing recession.Sites with large bone-cartilage interface deviations, both proud and recessed, were associated with recessed articular surfaces and low cartilage stiffness.The effectiveness of cartilage repair by osteochondral grafting is associated with the match of 3-D cartilage and bone geometry to the native osteochondral structure.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, University of California, San Diego.

ABSTRACT

Objective: The articular cartilage of autologous osteochondral grafts is typically different in structure and function from local host cartilage and thereby presents a remodeling challenge. The hypothesis of this study was that properties of the articular cartilage of trochlear autografts and adjacent femoral condyle are associated with the 3-D geometrical match between grafted and contralateral joints at 6 and 12 months after surgery.

Design: Autografts were transferred unilaterally from the lateral trochlea (LT) to the medial femoral condyle (MFC) in adult Spanish goats. Operated and contralateral Non-Operated joints were harvested at 6 and 12 months, and analyzed by indentation testing, micro-computed tomography, and histology to compare (1) histological indices of repair, (2) 3-D structure (articular surface deviation, bone-cartilage interface deviation, cartilage thickness), (3) indentation stiffness, and (4) correlations between stiffness and 3-D structure.

Results: Cartilage deterioration was present in grafts at 6 months and more severe at 12 months. Cartilage thickness and normalized stiffness of Operated MFC were lower than Non-Operated MFC within the graft and proximal adjacent host regions. Operated MFC articular surfaces were recessed relative to Non-Operated MFC and exhibited lower cartilage stiffness with increasing recession. Sites with large bone-cartilage interface deviations, both proud and recessed, were associated with recessed articular surfaces and low cartilage stiffness.

Conclusion: The effectiveness of cartilage repair by osteochondral grafting is associated with the match of 3-D cartilage and bone geometry to the native osteochondral structure.

No MeSH data available.


Related in: MedlinePlus

Three-dimensional bone reconstructions showing a variably proud bone-cartilage interface with respect to the adjacent host (A) with and (B) without a transparent cartilage layer overlaid on top of the bone.
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fig5-1947603511435272: Three-dimensional bone reconstructions showing a variably proud bone-cartilage interface with respect to the adjacent host (A) with and (B) without a transparent cartilage layer overlaid on top of the bone.

Mentions: The articular surfaces across all operated adjacent host and graft regions were recessed relative to contralateral nonoperated regions (Fig. 4). The average graft region was recessed by 0.24 mm at 6 months and 0.37 mm at 12 months (P < 0.005). The bone-cartilage interface of the grafts tended to be proud relative to the nonoperated, with a ring of recessed host bone immediately surrounding the graft (Fig. 4E and 4F). 3-D reconstructions of graft cartilage and bone showed variability of the bone-cartilage interface (Fig. 5).


Association of 3-Dimensional Cartilage and Bone Structure with Articular Cartilage Properties in and Adjacent to Autologous Osteochondral Grafts after 6 and 12 months in a Goat Model.

Chan EF, Liu IL, Semler EJ, Aberman HM, Simon TM, Chen AC, Truncale KG, Sah RL - Cartilage (2012)

Three-dimensional bone reconstructions showing a variably proud bone-cartilage interface with respect to the adjacent host (A) with and (B) without a transparent cartilage layer overlaid on top of the bone.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3818730&req=5

fig5-1947603511435272: Three-dimensional bone reconstructions showing a variably proud bone-cartilage interface with respect to the adjacent host (A) with and (B) without a transparent cartilage layer overlaid on top of the bone.
Mentions: The articular surfaces across all operated adjacent host and graft regions were recessed relative to contralateral nonoperated regions (Fig. 4). The average graft region was recessed by 0.24 mm at 6 months and 0.37 mm at 12 months (P < 0.005). The bone-cartilage interface of the grafts tended to be proud relative to the nonoperated, with a ring of recessed host bone immediately surrounding the graft (Fig. 4E and 4F). 3-D reconstructions of graft cartilage and bone showed variability of the bone-cartilage interface (Fig. 5).

Bottom Line: Operated MFC articular surfaces were recessed relative to Non-Operated MFC and exhibited lower cartilage stiffness with increasing recession.Sites with large bone-cartilage interface deviations, both proud and recessed, were associated with recessed articular surfaces and low cartilage stiffness.The effectiveness of cartilage repair by osteochondral grafting is associated with the match of 3-D cartilage and bone geometry to the native osteochondral structure.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, University of California, San Diego.

ABSTRACT

Objective: The articular cartilage of autologous osteochondral grafts is typically different in structure and function from local host cartilage and thereby presents a remodeling challenge. The hypothesis of this study was that properties of the articular cartilage of trochlear autografts and adjacent femoral condyle are associated with the 3-D geometrical match between grafted and contralateral joints at 6 and 12 months after surgery.

Design: Autografts were transferred unilaterally from the lateral trochlea (LT) to the medial femoral condyle (MFC) in adult Spanish goats. Operated and contralateral Non-Operated joints were harvested at 6 and 12 months, and analyzed by indentation testing, micro-computed tomography, and histology to compare (1) histological indices of repair, (2) 3-D structure (articular surface deviation, bone-cartilage interface deviation, cartilage thickness), (3) indentation stiffness, and (4) correlations between stiffness and 3-D structure.

Results: Cartilage deterioration was present in grafts at 6 months and more severe at 12 months. Cartilage thickness and normalized stiffness of Operated MFC were lower than Non-Operated MFC within the graft and proximal adjacent host regions. Operated MFC articular surfaces were recessed relative to Non-Operated MFC and exhibited lower cartilage stiffness with increasing recession. Sites with large bone-cartilage interface deviations, both proud and recessed, were associated with recessed articular surfaces and low cartilage stiffness.

Conclusion: The effectiveness of cartilage repair by osteochondral grafting is associated with the match of 3-D cartilage and bone geometry to the native osteochondral structure.

No MeSH data available.


Related in: MedlinePlus