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Association of 3-Dimensional Cartilage and Bone Structure with Articular Cartilage Properties in and Adjacent to Autologous Osteochondral Grafts after 6 and 12 months in a Goat Model.

Chan EF, Liu IL, Semler EJ, Aberman HM, Simon TM, Chen AC, Truncale KG, Sah RL - Cartilage (2012)

Bottom Line: Operated MFC articular surfaces were recessed relative to Non-Operated MFC and exhibited lower cartilage stiffness with increasing recession.Sites with large bone-cartilage interface deviations, both proud and recessed, were associated with recessed articular surfaces and low cartilage stiffness.The effectiveness of cartilage repair by osteochondral grafting is associated with the match of 3-D cartilage and bone geometry to the native osteochondral structure.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, University of California, San Diego.

ABSTRACT

Objective: The articular cartilage of autologous osteochondral grafts is typically different in structure and function from local host cartilage and thereby presents a remodeling challenge. The hypothesis of this study was that properties of the articular cartilage of trochlear autografts and adjacent femoral condyle are associated with the 3-D geometrical match between grafted and contralateral joints at 6 and 12 months after surgery.

Design: Autografts were transferred unilaterally from the lateral trochlea (LT) to the medial femoral condyle (MFC) in adult Spanish goats. Operated and contralateral Non-Operated joints were harvested at 6 and 12 months, and analyzed by indentation testing, micro-computed tomography, and histology to compare (1) histological indices of repair, (2) 3-D structure (articular surface deviation, bone-cartilage interface deviation, cartilage thickness), (3) indentation stiffness, and (4) correlations between stiffness and 3-D structure.

Results: Cartilage deterioration was present in grafts at 6 months and more severe at 12 months. Cartilage thickness and normalized stiffness of Operated MFC were lower than Non-Operated MFC within the graft and proximal adjacent host regions. Operated MFC articular surfaces were recessed relative to Non-Operated MFC and exhibited lower cartilage stiffness with increasing recession. Sites with large bone-cartilage interface deviations, both proud and recessed, were associated with recessed articular surfaces and low cartilage stiffness.

Conclusion: The effectiveness of cartilage repair by osteochondral grafting is associated with the match of 3-D cartilage and bone geometry to the native osteochondral structure.

No MeSH data available.


Related in: MedlinePlus

Surface deviations in the graft and proximal and distal adjacent host (PAHC, DAHC) regions at 6 and 12 months. Surface height deviation (A, B) profiles along the central test path and (C-F) spatial maps of the operated articular surface (AS) and bone-cartilage interface (BCI) with respect to matching contralateral nonoperated joints, depicting proud or recessed surfaces. Horizontal dashed lines on surface maps indicate location of the central test path. Vertical dashed lines indicate approximate positions of the interfaces between the PAHC, graft, and DAHC. Data are shown as mean ± SEM.
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fig4-1947603511435272: Surface deviations in the graft and proximal and distal adjacent host (PAHC, DAHC) regions at 6 and 12 months. Surface height deviation (A, B) profiles along the central test path and (C-F) spatial maps of the operated articular surface (AS) and bone-cartilage interface (BCI) with respect to matching contralateral nonoperated joints, depicting proud or recessed surfaces. Horizontal dashed lines on surface maps indicate location of the central test path. Vertical dashed lines indicate approximate positions of the interfaces between the PAHC, graft, and DAHC. Data are shown as mean ± SEM.

Mentions: The articular surfaces across all operated adjacent host and graft regions were recessed relative to contralateral nonoperated regions (Fig. 4). The average graft region was recessed by 0.24 mm at 6 months and 0.37 mm at 12 months (P < 0.005). The bone-cartilage interface of the grafts tended to be proud relative to the nonoperated, with a ring of recessed host bone immediately surrounding the graft (Fig. 4E and 4F). 3-D reconstructions of graft cartilage and bone showed variability of the bone-cartilage interface (Fig. 5).


Association of 3-Dimensional Cartilage and Bone Structure with Articular Cartilage Properties in and Adjacent to Autologous Osteochondral Grafts after 6 and 12 months in a Goat Model.

Chan EF, Liu IL, Semler EJ, Aberman HM, Simon TM, Chen AC, Truncale KG, Sah RL - Cartilage (2012)

Surface deviations in the graft and proximal and distal adjacent host (PAHC, DAHC) regions at 6 and 12 months. Surface height deviation (A, B) profiles along the central test path and (C-F) spatial maps of the operated articular surface (AS) and bone-cartilage interface (BCI) with respect to matching contralateral nonoperated joints, depicting proud or recessed surfaces. Horizontal dashed lines on surface maps indicate location of the central test path. Vertical dashed lines indicate approximate positions of the interfaces between the PAHC, graft, and DAHC. Data are shown as mean ± SEM.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3818730&req=5

fig4-1947603511435272: Surface deviations in the graft and proximal and distal adjacent host (PAHC, DAHC) regions at 6 and 12 months. Surface height deviation (A, B) profiles along the central test path and (C-F) spatial maps of the operated articular surface (AS) and bone-cartilage interface (BCI) with respect to matching contralateral nonoperated joints, depicting proud or recessed surfaces. Horizontal dashed lines on surface maps indicate location of the central test path. Vertical dashed lines indicate approximate positions of the interfaces between the PAHC, graft, and DAHC. Data are shown as mean ± SEM.
Mentions: The articular surfaces across all operated adjacent host and graft regions were recessed relative to contralateral nonoperated regions (Fig. 4). The average graft region was recessed by 0.24 mm at 6 months and 0.37 mm at 12 months (P < 0.005). The bone-cartilage interface of the grafts tended to be proud relative to the nonoperated, with a ring of recessed host bone immediately surrounding the graft (Fig. 4E and 4F). 3-D reconstructions of graft cartilage and bone showed variability of the bone-cartilage interface (Fig. 5).

Bottom Line: Operated MFC articular surfaces were recessed relative to Non-Operated MFC and exhibited lower cartilage stiffness with increasing recession.Sites with large bone-cartilage interface deviations, both proud and recessed, were associated with recessed articular surfaces and low cartilage stiffness.The effectiveness of cartilage repair by osteochondral grafting is associated with the match of 3-D cartilage and bone geometry to the native osteochondral structure.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, University of California, San Diego.

ABSTRACT

Objective: The articular cartilage of autologous osteochondral grafts is typically different in structure and function from local host cartilage and thereby presents a remodeling challenge. The hypothesis of this study was that properties of the articular cartilage of trochlear autografts and adjacent femoral condyle are associated with the 3-D geometrical match between grafted and contralateral joints at 6 and 12 months after surgery.

Design: Autografts were transferred unilaterally from the lateral trochlea (LT) to the medial femoral condyle (MFC) in adult Spanish goats. Operated and contralateral Non-Operated joints were harvested at 6 and 12 months, and analyzed by indentation testing, micro-computed tomography, and histology to compare (1) histological indices of repair, (2) 3-D structure (articular surface deviation, bone-cartilage interface deviation, cartilage thickness), (3) indentation stiffness, and (4) correlations between stiffness and 3-D structure.

Results: Cartilage deterioration was present in grafts at 6 months and more severe at 12 months. Cartilage thickness and normalized stiffness of Operated MFC were lower than Non-Operated MFC within the graft and proximal adjacent host regions. Operated MFC articular surfaces were recessed relative to Non-Operated MFC and exhibited lower cartilage stiffness with increasing recession. Sites with large bone-cartilage interface deviations, both proud and recessed, were associated with recessed articular surfaces and low cartilage stiffness.

Conclusion: The effectiveness of cartilage repair by osteochondral grafting is associated with the match of 3-D cartilage and bone geometry to the native osteochondral structure.

No MeSH data available.


Related in: MedlinePlus