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Abundant immunoglobulin E-positive cells in skin lesions support an allergic etiology of atopic dermatitis in the elderly.

Tanei R, Hasegawa Y, Sawabe M - J Eur Acad Dermatol Venereol (2012)

Bottom Line: Comparative analysis of single immunohistochemistry results using serial paraffin and/or frozen sections found that many IgE+ cells showed identical distributions to tryptase+ mast cells.IgE+ cells coincident with CD1a+ Langerhans cells in the epidermis were found in small numbers only in frozen sections.IgE-mediated allergic inflammation may play an important role in the pathobiology of elderly AD, similar to other age groups of AD.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan. rtanei@aol.com

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Skin manifestations of elderly AD: extrinsic form, Cases 1–3; intrinsic form, Case 4 (a) Lichenified eczema on the upper back (Case 1). (b) Facial erythema (atopic red face) with Hertogh’s sign (loss of lateral eyebrows) and Dennie-Morgan infraorbital folds (Case 2). (c) Dirty neck (Case 2). (d) Lichenified eczema around the scarcely involved elbow fold (reverse sign) (Case 2). (e) Eczematous erythroderma (Case 3). (f) Eczematous lesions mostly disappeared after successful treatment and the cured skin shows a normal appearance (Case 3). (g) Lichenified eczema of erythroderma on the trunk and neck (Case 4).
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fig01: Skin manifestations of elderly AD: extrinsic form, Cases 1–3; intrinsic form, Case 4 (a) Lichenified eczema on the upper back (Case 1). (b) Facial erythema (atopic red face) with Hertogh’s sign (loss of lateral eyebrows) and Dennie-Morgan infraorbital folds (Case 2). (c) Dirty neck (Case 2). (d) Lichenified eczema around the scarcely involved elbow fold (reverse sign) (Case 2). (e) Eczematous erythroderma (Case 3). (f) Eczematous lesions mostly disappeared after successful treatment and the cured skin shows a normal appearance (Case 3). (g) Lichenified eczema of erythroderma on the trunk and neck (Case 4).

Mentions: A 79-year-old man with hypertension, chronic kidney disease and senile depression complained of chronic eczema for 3 years. He showed mild eczematous dermatitis on the face and upper extremities and significant lichenified eczema on the nape and upper back (Fig. 1a). He also showed symptomatic allergic conjunctivitis, but had no family history of atopic disorders.


Abundant immunoglobulin E-positive cells in skin lesions support an allergic etiology of atopic dermatitis in the elderly.

Tanei R, Hasegawa Y, Sawabe M - J Eur Acad Dermatol Venereol (2012)

Skin manifestations of elderly AD: extrinsic form, Cases 1–3; intrinsic form, Case 4 (a) Lichenified eczema on the upper back (Case 1). (b) Facial erythema (atopic red face) with Hertogh’s sign (loss of lateral eyebrows) and Dennie-Morgan infraorbital folds (Case 2). (c) Dirty neck (Case 2). (d) Lichenified eczema around the scarcely involved elbow fold (reverse sign) (Case 2). (e) Eczematous erythroderma (Case 3). (f) Eczematous lesions mostly disappeared after successful treatment and the cured skin shows a normal appearance (Case 3). (g) Lichenified eczema of erythroderma on the trunk and neck (Case 4).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3818699&req=5

fig01: Skin manifestations of elderly AD: extrinsic form, Cases 1–3; intrinsic form, Case 4 (a) Lichenified eczema on the upper back (Case 1). (b) Facial erythema (atopic red face) with Hertogh’s sign (loss of lateral eyebrows) and Dennie-Morgan infraorbital folds (Case 2). (c) Dirty neck (Case 2). (d) Lichenified eczema around the scarcely involved elbow fold (reverse sign) (Case 2). (e) Eczematous erythroderma (Case 3). (f) Eczematous lesions mostly disappeared after successful treatment and the cured skin shows a normal appearance (Case 3). (g) Lichenified eczema of erythroderma on the trunk and neck (Case 4).
Mentions: A 79-year-old man with hypertension, chronic kidney disease and senile depression complained of chronic eczema for 3 years. He showed mild eczematous dermatitis on the face and upper extremities and significant lichenified eczema on the nape and upper back (Fig. 1a). He also showed symptomatic allergic conjunctivitis, but had no family history of atopic disorders.

Bottom Line: Comparative analysis of single immunohistochemistry results using serial paraffin and/or frozen sections found that many IgE+ cells showed identical distributions to tryptase+ mast cells.IgE+ cells coincident with CD1a+ Langerhans cells in the epidermis were found in small numbers only in frozen sections.IgE-mediated allergic inflammation may play an important role in the pathobiology of elderly AD, similar to other age groups of AD.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan. rtanei@aol.com

Show MeSH
Related in: MedlinePlus