Abundant immunoglobulin E-positive cells in skin lesions support an allergic etiology of atopic dermatitis in the elderly.
Bottom Line: Comparative analysis of single immunohistochemistry results using serial paraffin and/or frozen sections found that many IgE+ cells showed identical distributions to tryptase+ mast cells.IgE+ cells coincident with CD1a+ Langerhans cells in the epidermis were found in small numbers only in frozen sections.IgE-mediated allergic inflammation may play an important role in the pathobiology of elderly AD, similar to other age groups of AD.
Affiliation: Department of Dermatology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan. email@example.comShow MeSH
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Mentions: A 79-year-old man with hypertension, chronic kidney disease and senile depression complained of chronic eczema for 3 years. He showed mild eczematous dermatitis on the face and upper extremities and significant lichenified eczema on the nape and upper back (Fig. 1a). He also showed symptomatic allergic conjunctivitis, but had no family history of atopic disorders.
Affiliation: Department of Dermatology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan. firstname.lastname@example.org