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Aggression and polymorphisms in AR, DAT1, DRD2, and COMT genes in Datoga pastoralists of Tanzania.

Butovskaya ML, Vasilyev VA, Lazebny OE, Suchodolskaya EM, Shibalev DV, Kulikov AM, Karelin DV, Burkova VN, Mabulla A, Ryskov AP - Sci Rep (2013)

Bottom Line: The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga.Among the genes of the dopaminergic system, a significant single-gene effect was detected only for DRD2 with regard to anger.At the level of a two-gene model, a significant effect for DRD2 and a tendency for DAT1 were observed for the DAT1-DRD2 gene pair regarding hostility, and two tendencies were observed for the interaction effect of the DAT1-COMT pair regarding anger and hostility.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Cross-Cultural Psychology and Human Ethology, Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow, 119991, Russia [2].

ABSTRACT
The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga. Buss and Perry's Aggression Questionnaire was used to measure aggression. The number of CAG repeats in the AR gene was negatively correlated with physical aggression, anger, and hostility. Among the genes of the dopaminergic system, a significant single-gene effect was detected only for DRD2 with regard to anger. At the level of a two-gene model, a significant effect for DRD2 and a tendency for DAT1 were observed for the DAT1-DRD2 gene pair regarding hostility, and two tendencies were observed for the interaction effect of the DAT1-COMT pair regarding anger and hostility. These data suggest a probable link between physical aggression and direct fitness caused by strong sexual selection in Datoga men.

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Related in: MedlinePlus

The distribution of the anger (A) and hostility (B) as correlated with the DAT1 × COMT effect.The designations of the ordinate numbers are described in Figure 1.
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f3: The distribution of the anger (A) and hostility (B) as correlated with the DAT1 × COMT effect.The designations of the ordinate numbers are described in Figure 1.

Mentions: We subsequently performed a factorial two-way ANOVA to test both the main and interaction effects of the three genes (DAT1, DRD2, and COMT) on three aggression subscales (Tables 4). The two-gene model revealed two significant main effects of the DRD2 gene on anger and hostility, showing a tendency for a main effect of DAT1 on hostility. Tendencies of DAT1 × COMT interaction effects on anger and hostility, but not on physical aggression, were also observed (Fig. 3a,b).


Aggression and polymorphisms in AR, DAT1, DRD2, and COMT genes in Datoga pastoralists of Tanzania.

Butovskaya ML, Vasilyev VA, Lazebny OE, Suchodolskaya EM, Shibalev DV, Kulikov AM, Karelin DV, Burkova VN, Mabulla A, Ryskov AP - Sci Rep (2013)

The distribution of the anger (A) and hostility (B) as correlated with the DAT1 × COMT effect.The designations of the ordinate numbers are described in Figure 1.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3818681&req=5

f3: The distribution of the anger (A) and hostility (B) as correlated with the DAT1 × COMT effect.The designations of the ordinate numbers are described in Figure 1.
Mentions: We subsequently performed a factorial two-way ANOVA to test both the main and interaction effects of the three genes (DAT1, DRD2, and COMT) on three aggression subscales (Tables 4). The two-gene model revealed two significant main effects of the DRD2 gene on anger and hostility, showing a tendency for a main effect of DAT1 on hostility. Tendencies of DAT1 × COMT interaction effects on anger and hostility, but not on physical aggression, were also observed (Fig. 3a,b).

Bottom Line: The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga.Among the genes of the dopaminergic system, a significant single-gene effect was detected only for DRD2 with regard to anger.At the level of a two-gene model, a significant effect for DRD2 and a tendency for DAT1 were observed for the DAT1-DRD2 gene pair regarding hostility, and two tendencies were observed for the interaction effect of the DAT1-COMT pair regarding anger and hostility.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Cross-Cultural Psychology and Human Ethology, Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow, 119991, Russia [2].

ABSTRACT
The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga. Buss and Perry's Aggression Questionnaire was used to measure aggression. The number of CAG repeats in the AR gene was negatively correlated with physical aggression, anger, and hostility. Among the genes of the dopaminergic system, a significant single-gene effect was detected only for DRD2 with regard to anger. At the level of a two-gene model, a significant effect for DRD2 and a tendency for DAT1 were observed for the DAT1-DRD2 gene pair regarding hostility, and two tendencies were observed for the interaction effect of the DAT1-COMT pair regarding anger and hostility. These data suggest a probable link between physical aggression and direct fitness caused by strong sexual selection in Datoga men.

Show MeSH
Related in: MedlinePlus